Anup Kumar Misra, Ph.D.

Associate Professor
Division of Molecular Medicine
Ph.D: Indian Association for the Cultivation of Science (IACS), Calcutta, (Jadavpur University) 1997.

Tel: 91-33-2569-3240
Fax:  91-33-2355-3886

E-mail: akmisra69@gmail.com
             anup@bic.boseinst.ernet.in



Research interest

Main research interest is to develop synthetic strategies for the synthesis of complex saccharide molecules of biological interest and their glycoconjugates to use them in the immunochemical studies towards the preparation of anti-microbial agents.

The group is also engaged in the design and synthesis of medicinally important small molecules (e.g. anticancer agents, antioxidantsis and enzyme inhibitors) and their bioevaluation in a collaborative program.

Professional awards/recognitions

 

  1. Received CSIR Young Scientist Award 2005 in Chemical Sciences.
  2. Received DST Ramanna Research Fellowship 2007 (2007-2010).
  3. Visiting scientist (University of Konstanz, Germany) under INSA-DFG bilateral exchange program (March-May 2009).

 

Name of present group members

 

§  Goutam Guchhait, CSIR-SRF

§  Abhishek Santra, CSIR-SRF

§  Abhijit Sau, CSIR-SRF

§  Manas Jana, CSIR-JRF

§  Ms. Tamashree Ghosh, CSIR-JRF

§  Debasish Majumder, Senior Lab. Asstt.

 

Name of former group members

 

§  Dr. (Ms.) Geetanjali Agnihotri

§  Dr. (Ms.) Pallavi Tiwari

§  Dr. Rishi Kumar (with Dr. P.R. Maulik, CDRI, Lko) (currently at NRC, Canada)

§  Dr. Soni Kamlesh Madhusudan

§  Dr. Chinmoy Mukherjee  (currently at Univ. of Iowa, USA)

§  Dr. Pintu Kumar Mandal (currently at Univ. of Georgia, USA)

§  Dr. Rajib Panchadhayee (currently at Abo Academy, Finland)

§  Dr. Samir Ghosh (currently at NIH, Bathesda, USA)

 

Selected list of Publications 

1.      Rajib panchadhayee and Anup Kumar Misra, Convergent synthesis of the pentasaccharide repeating unit of the O-antigen of Shigella boydii type 14, Tetrahedron: Asymmetry (2011) 22, 1390-1394.

2.      Abhishek Santra and Anup Kumar Misra, Convergent synthesis of the tetrasaccharide repeating unit of the O-antigen of Shigella boydii type 9, Beilstein J. Org. Chem (2011) 7, 1182-1188.

3.      Goutam Guchhait and Anup Kumar Misra, Efficient glycosylation of unprotected sugars using sulfamic acid: a mild eco-friendly catalyst, Catalysis Communications (2011) 14, 52-57.

4.      Goutam Guchhait, Anup K.Misra, Convergent synthesis of a common pentasaccharide corresponding to the O-antigen of Escherichia coli O168 and Shigella dysenteriae type 4 , Glycoconjugate Journal (2011) 28, 11-19.

5.      Abhishek Santra, Goutam Guchhait, Anup Kumar Misra, Efficient acylation and sulfation of carbohydrates using sulfamic acid, a mild, eco-friendly catalyst under organic solvent-free condition. Green Chemistry (2011) 13, 1345-51.

6.      C. Mukherjee, S. Ghosh, P. Nandi, P. C. Sen and Anup K. Misra, Efficient synthesis of (6-deoxy-glycopyranosid-6-yl)-sulfone derivatives and their effect on Ca2+-ATPase. Eur. J. Med. Chem. (2010) 45, 6012-6019.

7.      Samir Ghosh and Anup Kumar Misra, Synthesis of the hexasacch-aride repeating unit corres-ponding to the cell wall lipopolysaccharide of Azo-spirillum irakense KBC1, Tetrahedron: Asymmetry (2010) 21, 2755-2761.

8.      Panchadhayee, R. and Misra, A. K., Convergent synthesis of a common pentasaccharide repeating unit corresponding to the O-specific polysaccharide of Escheriachia coli O4: K3, O4:K6 and O4:K12. Tetrahedron: Asymmetry  (2010) 21, 859-863.

9.      Panchadhayee, R. and Misra, A. K., Convenient synthesis of a hexasaccharide corresponding to the O-antigen of Escherichia coli O150. Tetrahedron: Asymmetry (2010) 21, 2142.

10.  Rajib Panchadhayee and Anup K. Misra,  Regioselective reductive ring-opening of benzylidene acetals using triethylsilane and iodine. Synlett (2010) 1193-1196.

11.  Ghosh, S.  and Misra, A. K., Concise synthesis of a hexasaccharide present in the cell wall lipopolysaccharide of Azospirillum lipoferum Sp59b. Tetrahedron: Asymmetry, (2010) 21, 725-730.

12.  Pintu Kumar Mandal and Anup Kumar Misra,  Concise Synthesis of the pentasaccharide O-antigen corresponding to the Shiga toxin producing Escherichia Coli O171. Bioorganic Chemistry (2010) 38, 56-61.

13.  Samir Ghosh and Anup Kumar Misra,  Synthesis of a tetra-saccharide corresponding to the teichoic acid from the cell wall of Strepto-myces sp. VKM Ac-2275. Tetrahedron: Asymmetry (2009) 20, 2688-93.

14.  Goutam Guchhait and Anup Kumar Misra,  Total synthesis of the heptasaccharide of the iron-binding exopoly-saccharide secreted by Klebsiela oxytoca BAS-10. Tetrahedron: Asymmetry (2009) 20, 1791-1797.

15.  Shashi Pandey, Samir Ghosh and Anup Kumar Misra,  Synthesis of a tri and tetrasaccharide present in the cellwall lipopolysaccharides of Azospirilum brasilenseS17. Synthesis (2009) 2584-2590.

16.  Pintu Kumar Mandal and Anup Kumar Misra,  Efficient synthesis of two sialylated tetrasaccharides found in goat milk, Synthesis (2009) 1348-1354.

17.  Total synthesis of a unique tetrasaccharide present in the Human Clotting Factor IX and mammalian Notch 1 receptor, Chinmoy Mukherjee, Anup Kumar Misra  Tetrahedron: Asymm. (2009) 20, 473-477.

18.  Rajib Panchadhayee and Anup Kumar Misra,  First synthesis of a pentasaccharide repeating unit of the O-antigenic polysaccharide from enterohemorrhagic E. coli O48:H21. Tetrahedron: Asymmetry (2009) 20, 1550-1555.

19.  S. Ghosh, Anup Kumar Misra,  G. Bhatia, M. Khan, A. Khanna, Syntheses and evaluation of glucosyl aryl thiosemi-carbazide and glucosyl thiosemicarbazone derivatives as antioxidant, anti-dyslipidemic agents. Bioorg. Med. Chem. Lett. (2009), 19, 386-389.

20.  Chinmoy Mukherjee and Anup Kumar Misra  Synthesis of a unique trisaccharide having an acetal linkage between open-chain and cyclic sugar found in the cell wall of Proteus. Tetrahedron: Asymm. (2008) 19, 2746-51.

21.  Rajib Panchadhayee, Anup Kumar Misra,  Concise synthesis of a heptasaccharide antigen found in the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990. Glycoconjugate J.  (2008), 25, 817-826.

22.  Pintu Kumar Mandal and Anup Kumar Misra,  Concise synthesis of the pentasaccharide O-antigen of Escherichia coli O83:K24:H31 present in the Colinfant vaccine. Glycoconjugate J. (2008), 25, 713-722.

23.  R. Kumar, P.R. Maulik, and Anup Kumar Misra,  Concise chemical synthesis of a tetrasaccharide repeating unit of the O-antigen of Hafnia alvei 10457. Glycoconjugate J. (2008), 25, 511-519.

24.  Pallavi Tiwari and   Anup Kumar Misra,  Synthesis of oligosaccharide fragments corresponding to the exopolysaccharide released by Streptococcus macedonicus  Sc 136. Glycoconjugate J.  (2008) 25, 85-99.

25.  Chinmoy Mukherjee and Anup K. Misra,  First total synthesis of a pentasaccharide repeating unit of the O-antigen of Hafnia alvei PCM 1529. Glycoconjugate J.  (2008) 25, 111-119.

26.  R. Kumar, P.R. Maulik, Anup Kumar Misra,  Significantly rapid access to glycosyl triazole and tetrzoles from reducing sugars in one-pot. Glycoconjugate J. (2008), 25, 595-602.

27.  S. Ghosh, P. Tiwari, S. Pandey, Anup K. Misra,  V.Chaturvedi, A. Gaikwad, S. Bhatnagar, S. Sinha, Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives. Bioorg. Med. Chem. Lett. (2008), 18, 4002-4005.

28.  Pintu Kumar Mandal and Anup Kumar Misra,  Concise synthesis of two pentasaccharides corresponding to the a-chain oligosaccharides of N. gonorrhoeae and N. meningitides. Tetrahedron (2008), 64, 8685-8691.

29.  Pintu Kumar Mandal and Anup Kumar Misra,  Synthesis of Oligosaccharides Corresp onding to the Polysaccharides of Lactobacillus and Thermophilus Strains. Synthesis (2007), 2660-66.

30.  Geetanjali Agnihotri, Pintu Kumar Mandal and Anup Kumar Misra,  Concise synthesis of two trisaccharide analogs related to the glycone constituent of Phanoside, a novel insulin releasing natural product. Tetrahedron (2007), 63, 7240-45.

31.  Chinmoy Mukherjee and Anup Kumar Misra,  Glycosylation and pyranose-furanose isomerization of carbohydrates using HClO4-SiO2: Synthesis of oligosaccharides containing galactofuranose. Synthesis (2007), 683-692.

32.  Pintu Kumar Mandal and Anup Kumar Misra,  Mild and efficient hydrolysis of thioglycosides to glycosyl hemiacetals using N-iodosaccharin. Synlett (2007) 1207-1210.

33.  Chinmoy Mukherjee, Anup Kumar Misra, Odorless preparation of thioglycosides and thio michael adducts of carbohydrate derivatives. J. Carbohydrate Chemistry (2007), 26, 213-221.

34.  Pallavi Tiwari and Anup Kumar Misra,  Synthesis of a pentasaccharide repeating unit of the extracellular polysaccharide produced by L. delbrueckii subsp. bulgaricus 291. J. Carbohydr. Chem. (2007) 26, 239-248.

35.  Geetanjali Agnihotri, Anup Kumar Misra, Facile synthesis of pyruvate ketals of carbohydrates. Tetrahedron Letters (2006) 47, 8493-97.

36.  Pallavi Tiwari, Anup Kumar Misra ,An Efficient Stereoselective Dihydroxylation of Glycals using a Bimetallic System, RuCl3/CeCl3/NaIO4. Journal of Organic Chemistry (2006), 71, 2911-2913

37.  Pallavi Tiwari and Anup Kumar Misra , Indium(I) iodide mediated efficient synthesis of selenoglycosides.  Tetrahedron Letters (2006), 47, 2345-2348.

38.  P. Tiwari, A. Puri, R. Chander, G. Bhatia, Anup Kumar Misra,  Synthesis and antihyperlipidemic activity of novel glycosyl fructose derivatives. Bioorg. Med. Chem. Letters (2006) 16, 6028-6033.

39.  Chinmoy Mukherjee, Pallavi Tiwari and Anup Kumar Misra, Synthesis of thio- and selenoglyco-sides by cleavage of dichalconides in the presence of zinc/zinc chloride and reaction with glycosyl bromides. Tetrahedron Letters (2006), 47, 441-445.

40.  Geetanjali Agnihotri and Anup Kumar Misra,  Mild and efficient method for the cleavage of benzylidene acetals using HClO4–SiO2 and direct conversion of acetals to acetates.  Tetrahedron Letters (2006), 47, 3653-3658.

41.  Rishi Kumar, Pallavi Tiwari, P. R. Maulik, Anup Kumar Misra, A Generalized Procedure for the One-Pot Preparation of Glycosyl Azides and Thioglycosides Directly from Unprotected Reducing Sugars under Phase-Transfer Reaction Conditions. European Journal of Organic Chemistry (2006), 74-79.

42.  Geetanjali Agnihotri, Anup Kumar Misra,  Synthesis of a di- and a trisaccharide related to the O-antigen of Escherichia coli O83: K24: H31. Carbohydrate Research (2006), 341, 2420-2425.

43.  Pallavi Tiwari and Anup Kumar Misra, Acylation of carbohydrates over Al2O3: preparation of partially and fully acylated carbohydrate derivatives and acetylated glycosyl chlorides. Carbohydrate Research  (2006), 341, 339-350.

44.  Geetanjali Agnihotri and Anup Kumar Misra, Fast oxidation of thioglycosides to glycosyl sulfones using KMnO4/CuSO4·5H2O under neutral reaction conditions. Carbohydrate Research (2006), 341, 275-280.

45.  Soni Kamlesh Madhusudan, Anup Kumar Misra,  Facile exchange of glycosylS,S-acetals to their O,O-acetals and preparation of glycofuranosides from acyclic glycosyl S,S-acetals under metal-free reaction conditions in the presence of 1,3-dibromo-5,5-dimethylhydantoin. Carbohydrate Research (2005), 340, 497-502.

46.  Geetanjali Agnihotri and Anup Kumar Misra, Fast and selective oxidation of thioglycosides to glycosyl sulfoxides using KF/m-CPBA. Tetrahedron Letters (2005), 46, 8113-8116.

47.  Soni Kamlesh Madhusudan, Anup Kumar Misra, Synthesis of a new type of glycosidic linkage: Acetal linked disaccharides and trisaccharides of acyclic and cyclic sugars. European Journal of Organic Chemistry (2005), 3196-3205.

48.  Anup Kumar Misra,  P. Tiwari, G. Agnihotri, Ferrier rearrangement catalyzed by HClO4-SiO2: Synthesis of 2,3-unsatura-ted glycopyranosides. Synthesis (2005), 260-266

49.  Pallavi Tiwari, G. Agnihotri,  Anup Kumar Misra, Synthesis of 2,3-unsaturated C-glycosides by HClO4-SiO2 catalyzed ferrier rearrangement of glycals. Carbohydrate Research (2005) 340, 749-752.

50.  P. Tiwari, R. Kumar and Anup Kumar Misra  Efficient acetylation of carbohydrates promoted by imidazole. Eur. J. Organic Chemistry (2005) 4265-4270.


 

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