Bablu Bhattacharya
Professor, Biochemistry
PhD: Indian Association for the Cultivation of Science (1974)

Research interest

The research interests are as follows:

• Identification of structural, functional and regulatory domains of tubulin
• To understand the mechanism of antimitotic drugs binding to tubulin.
• To understand the mechanism of chaperone-like activity of tubulin
  

Name of group members

• Prof. B. Bhattacharyya
• Mr. Tapas Kumar Manna
• Mr.Taradas Sarkar
• Ms. Suvroma Gupta
• Mr. Asim Kumar Poddar

Important publications (ten)

1. Sengupta S, Banerjee S, Chakrabarti G, Mahapatra P, Roy, S and Bhattacharyya B. (2000). NBD-isocolcemid-tubulin interaction : A novel one-step reaction involving no conformational adjustment of reactants. Biochemistry, 39, 2227-34.
2. Guha, S, Manna, TK, Das KP and Bhattacharyya B. (1998) Chaperon-like activity of tubulin. J Biol Chem, 273 (46), 30077-80.
3. Guha S and Bhattacharyya B. (1997). Refolding of urea-denaturation tubulin : recovery of native like structure and colchicines binding activity from partly unfolded states. Biochemistry, 36(43), 13208-13.
4. Banerjee S, Chakrabarti G and Bhattacharyya B. (1997). Colchicine binding to tubulin monomers : a mechanistic study. Biochemistry, 36(18), 5600-06.
5. Guha S, Rawat SS, Chattopadhyay A and Bhattacharyya B (1996). Tubulin conformation and dynamics : a red edge excitation shift study. Biochemistry, 35(41), 13426-33.
6. Chakrabarti G, Sengupta S and Bhattacharyya B (1996). Thermodynamics of colchicinoid-tubulin interactions. Role of B-ring and C-7 substituent. J Biol Chem, 271(6), 2897-901.
7. Sarkar N, Mukhopadhyay K, Parrack P and Bhattacharyya B (1995). Aging of tubulin monomers using 5,5'-bis(8-anilino-1-naphthalenesulfonate) as a probe. Biochemistry, 34(41), 13367-73.
8. Guha S and Bhattacharyya B (1995). A partially folded intermediate during tubulin unfolding : its detection and spectroscopic characterization. Biochemistry, 34(21), 6925-31.
9. Panda D, Roy S and Bhattacharyya B (1992). Reversible dimmer dissociation of tubulin S and tubulin detected by fluorescence anisotropy. Biochemistry, 31 (40) 9709-16.
10. Mazumdar M, Parrack PK, Mukhopadhyay K and Bhattacharyya B (1992). Bis-ANS as a specific inhibitor for microtubule-associated protein induced assembly of tubulin. Biochemistry, 31(28) 6470-74.