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Education
M.Sc
(Biotechnology), Indian Institute of Technology, Bombay.
Ph.D
(Chemistry), University of Lübeck, Germany.
Professional Experiences
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May 1999-Nov. 2000 |
Research Assistant, IIT Bombay |
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Dec. 2000-May 2004 |
Ph. D. at University of Lübeck,
Germany |
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June 2004-Aug. 2005 |
Postdoctoral Research Fellow, National University of
Singapore |
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Aug. 2005-Dec. 2010 |
Research Fellow,
Nanyang Technological University, Singapore |
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Feb. 2011-present |
Assistant Professor, Dept. of Biophysics, Bose Institute |
Research interest
The main focus of my lab
is to use the application of state-of-the art NMR spectroscopy and
other biophysical methods including CD, Fluorescence etc. in
conjunction with molecular modeling techniques to address the
following projects:
1. Designing of novel
antifreeze
peptides for their
potential applications in many areas such as medicine, agriculture
and industry.
2. Receptor-ligand
interaction study to develop structure based drug design.
3. Novel Antimicrobial
peptides (AMPs) to develop antimicrobial and antisepsis drugs.
4. Carbohydrate mimic
peptide based drug design.
LIST OF PUBLICATIONS (*corresponding author)
2013
1.
Jana J, Kar RK,
Ghosh A, Biswas A, Ghosh S, Bhunia A*, Chatterjee S*
(2013) Human Cathelicidin Peptide LL37
Bind Telomeric G-Quadruplex. Mol.
Biosys.
(In press).
2.
Kar RK, Suryadevara P,
Jana J, Bhunia A*, Chatterjee S* (2013)
Novel G-quadruple
Stabilizing Agents: In-silico Approach
and Dynamics. J. Biomol. Str.
Dynam. (In press).
2012
3.
Shah SHH1, Kar RK1, Asmawi AA, Rahman
MBA, Murad AMA, Mahadi NM, Basri M, Rahman RNZAR, Salleh AB,
Chatterjee S*, Tejo BA*, Bhunia A* (2012)
Solution Structures, Dynamics, and Ice Growth Inhibitory Activityof
Peptide Fragments Derived from an Antarctic Yeast Protein.
PLOS One,
7(11), e49788. ( 1
both authors contributed equally)
4.
Mohanram H, Nip A, Domadia PN, Bhunia A, Bhattacharjya S.
(2012) NMR structure, localization, and
vesicle fusion of chikungunya virus fusion Peptide.
Biochemistry,
51(40),
7863-72.
5.
Bhunia A, Mohanram
H, and Bhattacharjya S. (2012)
Structural Determinants
of the Specificity of a Membrane Binding Domain of the Scaffold
Protein Ste5 of Budding Yeast: Implications in Signaling by the
Scaffold Protein in MAPK Pathway.
Biochim. Biophys.
Acta,
1818(5),
1250-60.
6.
Bhunia A*, Bhattacharjya S, Chatterjee,
S. (2012)
Applications of Saturation Transfer Difference (STD) NMR in
Biological Systems. Drug Discov. Today, 17(9-10),
505-13.
2011
7.
Bhunia A,
Saravanan R, Mohanram H, Mangoni ML, Bhattacharjya S. (2011)
NMR structures and interactions of
temporin-1Tl and temporin-1Tb with lipopolysaccharide Micelles:
mechanistic insights into outer membrane permeabilization and
synergistic activity. J Biol
Chem.,
286(7), 24394-406.
2010
8. Domadia PN, Bhunia A,
Ramamoorthy A, Bhattacharjya S. (2010)
Structure, Interactions, and Antibacterial activities of MSI-594
derived mutant peptie MSI-594F5A in Lipolysaccharide Micelles: Role
of the Helical Hairpin Conformation in Outer-Membrane
Permeabilization. J. Am. Chem.
Soc.,
132 (51), 18417-28.
9. Bhunia A,
Vivekanandan S, Eckert T, Burg-Roderfeld M, Wechselberger R,
Romanuka J, Bächle D, Kornilov AV, von der Leith C-W, Barbero JJ,
Nifantiev N, Schachner M, Sewald N, Lütteke T, Gabius, H-J, Siebert
H-C. (2010) Why the structurally
different cyclic peptides can be glycomemtics of HNK-1?
J. Am. Chem. Soc,
132, 96-105.
10. Bhunia A,
Bhattacharjya S. (2010) Mapping Residue
Specific Contacts of Polymyxin B with Lipopolysaccharide by
Saturation Transfer Difference (STD) NMR: Insights into
Outer-membrane Disruption and Endotoxin Neutralization.
Biopolymers,
96, 273-287.
11. Bhunia A, Domadia
PN, Torres J, Ramamoorthy A, Bhattacharjya S. (2010)
NMR Structure of Pardaxin, a
Pore-Forming Antimicrobial Peptide, in Lipopolysaccharide Micelles:
Mechanism of Outer membrane Permeabilization.
J. Biol. Chem.,
285(6), 3883-95.
12.
Domadia PN,
Li YF,
Bhunia A,
Mohanram H,
Tan SM,
Bhattacharjya S.
(2010)
Functional and
structural characterization of the talin F0F1 domain.
Biochem. Biophys. Res. Commun.
391(1),
159-65.
13. Rathi S, Bhunia A,
Bhattacharjya S. (2010) Role of the
Central Hinge Region in the Structure
and Activity of
Melittin: Designing Non-toxic Antisepsis/Antimicrobial Agents.
Biochim. Biophys. Acta,
1798(2),
128-139.
(Invited Paper).
2009
14.
Bhunia A,
Mohanram H, Domadia PN, Bhattacharjya S. (2009)
Designed
b-Boomerang
Antiendotoxic and Antimicrobial Peptides: Structures and Activities
in Lipopolysaccharide.
J. Biol. Chem.,
284(33), 21991-2004.
(Selected for “Papers of the Week”)
(http://www.jbc.org/content/284/33/21991/suppl/DC1/-/2).
15.
Bhunia A,
Ramamoorthy A, Bhattacharjya S. (2009),
Helical Hairpin Structure of a Potent Antimicrobial Peptide MSI-594
in Lipopolysaccharide Micelles by NMR.
Chemistry: A European Journal,
15 (9), 2036-40.
16.
Bhunia A,
Tang XY, Mohanram H, Tan SM, Bhattacharjya S. (2009),
NMR Solution Conformations and
Interactions of Integrin
aLb2
Cytoplasmic Tails.
J. Biol.Chem.
284(6), 3873-84.
17.
Bhunia A,
Mohanram H, Bhattacharjya S. (2009),
Lipopolysaccharide bound structures of the active fragments of
fowlicidin-1, a cathelicidin family of antimicrobial and
antiendotoxic peptide from chicken, determined by transferred
nuclear overhauser effect spectroscopy.
Biopolymers,
92(1), 9-22.
(Selected for cover page).
18.
Bhunia A,
Domadia PN, Mohanram H, Bhattacharjya S. (2009),
NMR structural studies of the Ste11 SAM
domain in the dodecyl phosphocholine micelle.
Proteins: Structure, Function and
Bioinformatics,
74(2),
328-43.
2008
19.
Bhunia A,
Schwardt O, Gäthje H, Gao GP, Kelm S, Benie AJ, Hricovini M, Peters
T, Ernst B. (2008), Consistent bioactive
conformation of the Neu5Ac-a-(2®3)Gal
epitope upon lectin binding.
ChemBioChem,
9(18), 2941-5.
20.
Bhunia A,
Chua GL, Domadia PN, Warshakoon H, Cromer JR, David SA,
Bhattacharjya S. (2008), Interactions of
a designed peptide with lipopolysaccharide: Bound conformation and
anti-endotoxic activity. Biochem.
Biophys. Res. Commun., 369, 853-7.
21. Domadia PN, Bhunia A,
Sivaraman J, Swarup S, Dasgupta D. (2008),
Berberine targets assembly of
Escherichia coli cell division protein FtsZ.
Biochemistry,
47, 3225-34.
22. Bhunia A, Domadia
PN, Xu X, Gingras R, Ni F, Bhattacharjya S. (2008),
Equilibrium unfolding of the dimeric SAM
domain of MAPKKK Ste11 from the budding yeast: role of the
interfacial residues in structural stability and binding.
Biochemistry,
47, 651-9.
2007
23. Domadia PN, Bhunia A,
Swarup S, Sivaraman J, Dasgupta D. (2007),
Inhibition of bacterial cell division
protein FtsZ by cinnamaldehyde.
Biochem. Pharmacol.,
74, 831-40.
24. Bhunia A, Domadia
PN, Bhattacharjya S. (2007), Structural
and thermodynamic analyses of the interaction between melittin and
lipopolysaccharide. Biochim.
Biophys. Acta,
1768, 3282-91.
25. Bhattacharjya S, Domadia PN,
Bhunia A, Malladi S, David SA. (2007),
High-resolution solution structure of a
designed peptide bound to lipopolysaccharide: transferred nuclear
Overhauser effects, micelle selectivity, and anti-endotoxic
activity. Biochemistry,
46, 5864-74.
2006 and before
26. Zhang YH, Bhunia A,
Wan KF, Lee MC, Chan SL, Yu VC, Mok YK. (2006),
Chelerythrine and sanguinarine dock at
distinct sites on BclXL that are not the classic BH3 binding cleft.
J. Mol. Biol.,
364, 536-49.
27. Bhunia A,
Jayalakshmi V, Benie AJ, Schuster O, Kelm S, Rama Krishna N, Peters
T. (2004), Saturation transfer
difference NMR and computational modeling of a sialoadhesin-sialyl
lactose complex. Carbohydr. Res.,
339, 259-67 (Most
cited paper award from Elsevier publishers).
28.
Bhunia A,
Durani S, Wangikar PP.
(2001), Horseradish peroxidase catalyzed
degradation of industrially important dyes.
Biotechnol. Bioeng.,
72, 562-7.
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