Staffs of Biophysics Department The Department of Biophysics had been created at Centenary Campus, Bose Institute in September, 1983. Main Institutional Projects Structure, function, dynamics and characterisation of macromolecules and molecules of biological interest. Main Academic Activities & Interests Molecular organization & Structural Recognition. The structural basis of biological function. Crystallographic structure and modeling ofprotease system to understand differential binding affinity, key to specificity in biology specially for protease drug design protocol . Calotropin DII, a thiol Protease, is solved and electron density map & final refinement is completed. Co-crystallization and structure elucidation of small model complexes of amino acids and nucleotides in their supramolecular association have been done to understand molecular recognition in biology. Difference in cognate/noncognate tRNA - tRNA Synthetase interaction has been linked to a conformational change. Molecular basis of cooperativity in l-repressor operator system Development of a model for protein electron transfer. Installation of a functional 500 MHz FT-NMR Spectrometer for various structural work. Major Instrumental facilities A 500 MHz FT-NMR Spectrometer X-ray unit with camera fluoescence spectrometer FPLC HPLC PCR Other biochemical and biophysical instruments such as lyophilizer, refrigerated centrifuge, polarizing microscope, spectrophotometer Computers: several Pentium/486, Silicon graphics etc. Area of interest of the faculties AB -> X-ray crystallography, molecular modeling , Protein structure, Protein-nucleic acid interaction. Recognition phenomena in biological system and its application in drug design. GB -> Electron transfer, Protein structure analysis. SR -> Protein-nucleic acid interaction, NMR spectroscopy. Scholars / Post Docs / Research Associates About 12 at present Grants from sponsored project DBT, CSIR, UNDP, DST etc (5 Schemes in progress currently). Others About 12 (twelve) full length papers has been published in 1999-01 in reputed journals 11 Ph.D. produced Charges for facilities available at this department : Instrument Academic Institutes (in Rs.) Industry (in Rs.) FT - NMR spectrometer - 500MHz No No HPLC No No FPLC No No Refrigerated superseed Centrifuge No No UV-VIS Spectrometer No No Fluorescence Spectometer No No Lyophiliser No No PCR machine perkinelmer No No Silicongraphics workstation(O2) No No Column chromatographic with UV monitor No No Polarising Microscope No No Bose Institute reserves the right to limit usage of it's facilities to outside users.