Anup Kumar Misra

Anup Kumar Misra
Professor

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Research interests:

Main research interest is to develop synthetic strategies for the synthesis of complex saccharide molecules of biological interest and their glycoconjugates to use them in the immunochemical studies towards the preparation of anti-microbial vaccine candidates.

The group is also engaged in the design and synthesis of medicinally important small molecules (e.g. anti-filarial, anticancer agents, antioxidantsis and enzyme inhibitors etc ) and their bioevaluation in a collaborative program

Contact:

Address: Division of Molecular Medicine
Centenary Campus
Bose Institute
P-1/12 C.I.T. Scheme VII-M
Kolkata - 700054, India
E-Mail: anup[at]jcbose.ac.in
Phone: +91-33-25693240

Research:

1. Design and Syntheses of molecules for their biological evaluation

 (a) In continuation of our ongoing program on the synthesis and bioevaluation of natural products and their analogs a series of glycosyl trizolyl terpenoid derivatives were synthesized and evaluated for their anticancer activities against different cancer cells. Several compounds were found anticancer agents and their detailed biological studies are under progress.

(b) A series of analogs of Resveratrol, a well known anticancer agent were prepared and their evaluation as anti filarial agents and anticancer agents are under progress.

(c) A series of aryl bisindolylmethane derivatives were prepared using an eco-friendly condition in water and their evaluation as CA-ATPase modulator and anticancer agent is ongoing.

(d) Cell wall glycoconjugates corresponding to the Meningitidis type X and A (MenX and A) have been prepared by the synthesis of the respective cell wall polysaccharide fragments by chemical glycosylations and then coupled with tetanus toxoid protein. The glycol-protein conjugates were evaluated for their antigenic functions and found promising lead for the development of the meningococcal vaccines.

(e) A collaborative program has been initiated under DST twinning project for the isolation, characterization and bioevaluation of natural products and preparation of their synthetic analogs.

 2. Studies on synthetic organic chemistry particularly carbohydrate chemistry:

 A large number of complex oligosaccharides corresponding to the antigenic cell wall polysaccharides of pathogenic bacteria have been synthesized using several novel techniques. These synthetic oligosaccharides act as important precursors for the preparation of glycoconjugates by attaching them with appropriate proteins under reductive amination methodologies. Synthetic glycoconjugates will be used to raise antibodies against them for their application in the development of diagnostic markers as well as antimicrobial agents.

A number of synthesized oligosaccharides were subjected to Molecular dynamics simulation studies to get the conformational structural insights of the compounds for designing glycomimetics corresponding to these molecules.

Publications:

LIST OF PUBLICATIONS 

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Recognition:

    Teaching:

    PhD Course work coordinator: Structure elucidation and synthetic studies of bio-active medicinally important molecules.

    Integrated MSc course: classes taken in chemistry biology course.

    Present:

    No.

    Article Title

    Journal Title

    Authors

    159

    Facile Transformation of Nitriles into Thioamides: Application to C-Glycosyl Nitrile Derivatives

    ChemistrySelect 2017, 2, 1366 -69

    Tamashree Ghosh, Anshupriya Si, Anup Kumar Misra*

    158

    Concise Synthesis of a Pentasaccharide Repeating Unit Corresponding to the O-Antigen of Salmonella EntericaO51

    ChemistrySelect 2017, 2, 937-939

    Ishani Bhaumik, Anup Kumar Misra*

    157

    Global Association between Thermophilicity and Vancomycin Susceptibility in Bacteria

    Front. Microbiol. 2016, 7:412. doi: 10.3389/fmicb.2016.00412.

    C. Roy, M. Alam, S. Mandal, P. K. Haldar, S. Bhattacharya, T. Mukherjee, R. Roy, M. J. Rameez, Anup K. Misra, R. Chakraborty, A. K. Nanda, S. K. Mukhopadhyay, Wriddhiman Ghosh,

    156

    Phemindole, a synthetic di-indole derivative maneuvers the store operated calcium entry (SOCE) to induce potent anti-carcinogenic activity in human triple negative breast cancer cells

    Frontiers in Pharmacology (2016),7, 114/1-114/21.

    S. Chakraborty, S. Ghosh, B. Banerjee, A. Santra, A. Adhikary, Anup K. Misra, Parimal C. Sen,

    155

    Mephebrindole, a synthetic indole analog coordinates the crosstalk between p38MAPK and eIF2α/ATF4/CHOP signalling pathways for induction of apoptosis in human breast carcinoma cells

    Apoptosis (2016),21,1106-1124

    S. Chakraborty, S. Ghosh, B. Banerjee, A. Santra, J. Bhat, A. Adhikary, S. Chatterjee, Anup K.; Misra, Sen, Parimal C.

    154

    Expedient synthesis of the pentasaccharide repeatingunit of the O-antigen of Escherichia coli O86and its conformational analysis

    Glycoconj J (2016) 33, 887-896

    Ishani Bhaumik, Anup Kumar Misra*

    153

    Synthesis of a pentasaccharide repeating unit corresponding to the cell wall O-antigen of Escherichia coli O59 using iterative glycosylations in one pot

    Tetrahedron  (2016) 72, 4435-4441

    Anshupriya Si, Anup Kumar Misra*

    152

    Preparation of glycosyl thiourea derivatives from glycosyl azides using sulfamic acid and sodium iodide in one-pot

    Carbohydrate Research (2016) 434, 107-112

    Arin Gucchait, Manas Jana, Kuladip Jana, Anup Kumar Misra*

    151

    C-Cinnamoyl glycosides as a new class of anti-filarial agents

    Eur. J. Med. Chem  (2016) 114, 308-317

    Priya Roy, Debashis Dhara, Pravat Kumar Parida, Rajiv Kumar Kar, Anirban Bhunia, Kuladip Jana, Santi P. Sinha Babu,* Anup Kumar Misra*

    150

    Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives

    Free Rad. Biol. Med. (2016) 93, 130-144

    Niladri Mukherjee, Pravat Kumar Parida, Abhishek Santra, Tamashree Ghosh, Ananya Dutta, Kuladip Jana, Anup Kumar Misra,* Santi P. Sinha Babu*

    149

    Glycosylation of phenolic acceptors using benzoylated glycosyl trichloroacetimidate donors

    Carbohydrate Chemistry: Proven Synthetic Methods (2015), 3, 97-105.

    Jani Rahkila, Anup Kumar; Misra, Lorenzo  Guazzelli, Reko Leino,

    148

    Chemoselective hydration of glycosyl cyanides to C-glycosyl formamides using ruthenium complexes in aqueous media

    Tetrahedron Letters (2015) 56, 5995-5998

    Anup Kumar Misra, Éva Bokor, Sándor Kun, Evelin Bolyog-Nagy, Ágnes Kathó, Ferenc Joó, László Somsák*

    147

    Expedient synthesis of the pentasaccharide repeating unit of the polysaccharide O-antigen of Escherichia coli O11

    Chemistry Open (2016) 5, 47-50

    Anshupriya Si, Anup Kumar Misra*

    146

    Facile synthesis of the heptasaccharide repeating unit of the cell wall O-polysaccharide of enterotoxigenic Escherichia coli O139

    Chemistry Open (2015) 5, 43-46

    Tamashree Ghosh, Anup Kumar Misra*

    145

    Synthesis of di- and trisaccharides related to the O-polysaccharide of Shigella dysenteriae type 8

    J. Carbohydr. Chem. (2015) 34, 501-513

    Abhishek Santra,  Tamashree Ghosh and Anup Kumar Misra*

    144

    Convergent Synthesis of Oligosaccharide Fragments Corresponding to the Cell Wall O-Polysaccharide of Salmonella enterica O53

    Chemistry Open (2015) 4, 768-773.

    Debashis Dhara, Anup Kumar Misra*

    143

    Synthesis of trisaccharide and a tetrasaccharide repeating unit corresponding to the O-antigen of Shiga toxin producing Escherichia coli O177

    Tetrahedron  (2015) 71, 3960-3965

    Manas Jana, Anup Kumar Misra*

    142

    Synthesis of a tetrasaccharide and its glycoconjugate corresponding to the capsular polysaccharide of Neisseria meningitidis serogroup X and its immunochemical studies

     

    RSC: Adv. (2015) 5, 41332-41340

    K. R. Harale, N. B. Dumare, D. Singh, Anup K. Misra, Manoj K. Chhikara

    141

    Efficient synthesis of the pentasaccharide repeating unit of the O-antigenic polysaccharide of Escherichia coli O166 strain

    Synthesis (2015) 47, 83-88.

    Anshupriya Si, Anup Kumar Misra*

    140

    Expedient synthesis of a pentasaccharide related to the O-specific polysaccharide of Escherichia coli O117:K98:H4 strain

    RSC: Adv (2014) 4, 61589-61595

    Ishani Bhaumik, Anup Kumar Misra*

    139

    Synthesis of the pentasaccharide repeating unit of the O-antigen of Escherichia coli O175 using one-pot glycosylations and its conformational analysis

    Tetrahedron (2014) 70, 9262-9267

    Tamashree Ghosh, Rajiv Kumar Kar, Anirban Bhunia, Anup Kumar Misra*

    138

    Efficient synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O174 strain

    Carbohydr. Res. (2014) 399, 21-25.

    Ishani Bhaumik, Tamashree Ghosh and Anup K. Misra*

    137

    Synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O69 strain and its conformational analysis

    RSC Adv. (2014) 4, 37079-37084.

    Manas Jana, Rajiv Kumar Kar, Anirban Bhunia, Anup Kumar Misra*

    136

    Concise Synthesis of the Repeating Units of the Cell Wall Lipopolysaccharide of Azospirillum brasilense SR80

    Synthesis (2014) 1947-1953.

    Pintu Kumar Mandal, Debashis Dhara, and Anup Kumar Misra

    135

    Synthesis and evaluation of triazole linked glycosylated 18b-glycyrrhetinic acid derivatives as anticancer agents.

    Bioorganic Medicinal Chem. Letters (2014), 24, 3865-68.

    P. K. Parida, A. Sau, T. Ghosh, K. Jana, K. Biswas, S. Raha, Anup Kumar Misra*

    134

    Convergent synthesis and conformational analysis of the hexasaccharide repeating unit of the O-antigen of Shigella flexneri serotype 1d

    European  Journal of Organic Chemistry (2014) 4577-4584.

    Debashis Dhara, Rajiv Kumar Kar, Anirban Bhunia, Anup Kumar Misra*

    133

    Linear synthesis and conformational analysis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O13

    Carbohydrate Research (2014) 391, 9-15.

    A. Santra, A. Si, R. K. Kar, A. Bhunia, Anup Kumar Misra*

    132

    Synthesis of a pentasaccharide repeating unit of the O-antigen of enteroadherent Escherichia coli O154 strain

    Tetrahedron: Asymm. (2014), 25, 632-636

    Manas Jana, Abhijit Sau, Anup K. Misra*

    131

    Convergent synthesis of a pentasaccharide repeating unit corresponding to the cell wall O-antigen of Salmonella enteric O44.

    Tetrahedron: Asymmetry (2014) 25, 263-267.

    Debashis Dhara, Pintu Kumar Mandal, Anup Kumar Misra*

    130

    Convergent synthesis of a tetrasaccharide repeating unit of the O-specific polysaccharide from the cell wall lipopolysaccharide of Azospirillum brasilense strain Sp7.

    Beilstein J. Org. Chem. (2014) 10, 293-299.

    Pintu Kumar Mandal*,  Debashis Dhara and Anup Kumar Misra

    129

    Convergent synthesis of a hexasaccharide corresponding to the cell wall O-antigen of Escherichia coli O41             

    RSC Adv. (2014) 4, 54-60

    Tamashree Ghosh, Abhishek Santra and Anup Kumar Misra*

    Image Name Designation Department Campus Contact number Email
    profile image Ananya Dutta SRF Biophysics Centenary 25693322 ananya.dutta@mail.jcbose.ac.in
    profile image Anshupriya Si SRF Division of Molecular Medicine Centenary 25693240 anshupriya
    profile image Ishani Bhaumik SRF Division of Molecular Medicine Centenary 25693240 ishani
    profile image Pradip Shit JRF Division of Molecular Medicine Centenary iampradipshit@gmail.com
    profile image Tapasi Manna JRF Division of Molecular Medicine Centenary 25693240 tapasi.manna
    profile image Tapasi Manna JRF Division of Molecular Medicine Centenary 25693240 tapasi.manna

    Former:

    Mr. Debashis Dhara, CSIR-SRF

    Ms. Anshupriya Si, CSIR-SRF

    Ms. Ishani Bhaumik, CSIR-SRF

    Mr. Arin Gucchait, CSIR-JRF

    Ms. Tapashi Manna, UGC-JRF

    Ms. Ananya Dutta, SRF (Bose Institute)

    Mr. Debashis Majumder, Scientific Officer

    Group News:

    Two Junior Research Fellow positions are available in my laboratory. Interested candidates having M.Sc. in Organic Chemistry may directly write to me (E-mail: akmisra69@gmail.com/ anup@jcbose.ac.in). The candidate should have CSIR-JRF or UGC-JRF fellowship.