Prof. Gaurisankar Sa, Ph.D.
List of publications in reverse chronological order
Peer reviewed journals
Chakraborty J, Banerjee S, Ray P,
Hossain DMS, Bhattacharyya S, Adhikary A, Chattopadhyay S, Das T & Sa G.
Gain of cellular adaptation
due to prolong p53 impairment leads to
functional switch-over from
p53 to p73
during DNA damage in acute myeloid leukemia cells. J. Biol. Chem.
Hossain DMS, Bhattacharyya S, Das T, & Sa G.
The multi-targeted therapy for cancer regression.
(Invited submission), 2010
Sa G, Das T, Roy P, Banerjee S & Chakraborty J.
Oncogenes as molecular target for curcumin-induced cancer cell apoptosis.
Prospective in Cytology & Genetics
14: (In press), 2010
Mohanty S, Adhikary A,
Chakrabarty S, Sa G & Das T.
Operation ‘p53 Hunt’ to combat cancer: Theaflavins in action.
Frontiers in Biosciences
(Invited submission), 2010
Das T, Sa G, Saha S, Mukherjee S, Mazumdar M & Mukherjee S. p53, a tumor
suppressor at the crossroads of the oncogenic networks in cancer: Targeting
the ‘guardian of the genome’.
Prospective in Cytology & Genetics
14: (In press), 2010
Hossain D Md. S,
Mohanty S, Sen GS, Chattopadhyay S, Banerjee S, Chakraborty J, Das K, Sarkar
D, Das T
Curcumin reverses T cell‐mediated adaptive immune dysfunctions in
tumor‐bearing host. Cell. Mol. Immunol. 7: 306-315, 2010
Lahiry L, Saha B, Chakraborty J,
Banerjee S, Das K, Sa G & Das T.
Theaflavins target Fas/caspase-8 and Akt/pBad
pathways to induce apoptosis in p53-mutated human breast cancer cells.
Carcinogenesis 31:259-68, 2010
Das T, Sa G,
Saha B & Das K. Multifocal signal modulation therapy of cancer: Ancient weapon,
modern targets. Mol. Cell. Biochem.
Sa G, Das T, Banerjee S & Chakraborty J. Curcumin:
From exotic spice to modern anticancer drug. AA J Med Sci.
Chattopadhyay S, Bhattacharyya S, Saha B, Chakrabarty J, Mohanty S, Hossain
Banerjee S, Das K, Sa G & Das T. Tumor-shed PGE2 impairs
to inhibit CD4+ T cell survival: Regulation by theaflavins.
PLoS One 4:e7382, 2009
Chatterjee S, Mookerjee A, Mookerjee Basu J, Chakraborty P, Ganguly A,
Adhikary A, Mukhopadhyay D, Banerjee R, Ashraf M, Biswas J, Das PK, Sa G, Chatterjee
M, Das T & Chaudhuri SK. CuNG, a novel copper complex, modulates drug
resistant tumor associated macrohages to reprogram T cells to elicit
anti-tumor response. PLoS One 4:e7048,
Sa G, Das T, Moon C, Hilston CM, Rayman PA, Rini BI,
Tannenbaum CS & Finke JH.
GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the
Apoptosis of Activated but not Resting T Cells.
Lahiry L, Saha B, Chakraborty J, Bhattacharyya S,
Chattopadhyay S, Choudhuri T, Mandal D, Bhattacharyya A, Sa G &
Das T. Contribution of p53-mediated transcription-dependent pathway
in mammary epithelial carcinoma cell apoptosis by theaflavins.
Sa G, Paszkiewicz-Kozik E, Hilston C, Molto L, Rayman P, Biswas K, Kudo D,
Bukowski RM, Finke JH & Tannenbaum C. Tumors Induce T Cell Apoptosis Through
Receptor-Dependent and Receptor-Independent Pathways. J. Immunol.
and Sa G
both contributed equally to this paper]
Sa G, Hilston C, Kudo D, Rayman P, Biswas K, Molto L, Bukowski R, Rini B,
Finke JH & Tannenbaum C. GM1 and TNFa, overexpressed in renal cell
carcinoma, synergize to induce T cell apoptosis. Cancer Research
2008 [Das T
and Sa G
both contributed equally to this paper]
Sa G & Das T. Anti cancer effects of curcumin: cycle of life
Sa G, Chattopadhyay S & Saha B. Black tea: The Future Panacea for Cancer.
AA J Med Sci. 1:70-83, 2008
Bhattacharyya A, Mandal D, Lahiry L, Bhattacharyya S,
Chattopadhyay S, Ghosh UK, Sa G & Das T. Black Tea-Induced
Amelioration of Hepatic Oxidative Stress through Antioxidative Activity in
EAC-Bearing Mice. J Environ Pathol Toxicol Oncol.
Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T & Sa
G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated
Bcl-2 induction. J Biol Chem. 282:15954-64,
Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry
L, Finke JH, Tannenbum CS, Das T & Sa G. Tumor-induced oxidative
stress perturbs NFkB
activity augmenting TNFa-mediated
T cell death: Protection by curcumin. Cancer Research. 67:362-70,
Mandal D, Bhattacharyya S, Lahiry L, Chattopadhyay S, Sa G &
Das T. Black tea-induced decrease in IL-10 and TGF-b of tumor cells promotes Th1/Tc1
response in tumor-bearer. Nutrition Cancer
Raval G, Biswas S, Rayman P, Biswas K, Sa G, Ghosh S,
Thornton M, Hilston C, Das T, Bukowski R, Finke
J & Tannenbaum CS. TNF-α Induction of GM2 Expression on Renal
Cell Carcinomas Promotes T cell Dysfunction. J Immunol.
Dasgupta R, Saha I, Pal S, Bhattacharyya A, Sa G, Nag TC, Das
T & Maiti BR. Immunosuppression, hepatotoxicity and
depression of antioxidant status by arecoline. Toxicology 227:94-104,
Biswas K, Richmond A , Rayman P, Biswas S, Thornton M, Sa G,
Das T, Zhang R, Chahlavi A, Tannenbaum CS, Novick A, Bukowski R & Finke JH.
GM2 Expression in renal cell carcinoma: Potential role in tumor-induced
immune dysfunction. Cancer Research. 66:6816-25, 2006
Mookerjee A, Mookerjee Basu J, Dutta P, Majumder S,
Bhattacharyya S, Biswas J, Pal S, Mukherjee P, Raha S, Baral RN, Das T,
Efferth T, Sa G, Roy S & Choudhuri SK. Overcoming drug resistant cancer by a
newly developed copper chelate through host protective cytokine mediated
apoptosis. Clinical Cancer Research 12:4339-49, 2006
Sa G & Roy Chowdhury A. Inorganic lead exposure in battery and paint
factory: effect on human sperm structure and functional activity. J
UOEH 28, 157-171, 2006
Choudhuri T, Pal S, Das T & Sa G. Curcumin selectively
induces apoptosis in deregulated cyclin D1 expressed cells at G2 phase of
cell cycle in a p53-dependent manner.
J. Biol. Chem.
280:20059-68, 2005 [with front page cover citing the work].
Sa G, Guo Y & Stacey DW.
Regulation of S phase initiation by p27Kip1 in NIH3T3 cells.
Cell Cycle 4, 618-627, 2005 [with front page cover
citing the work]
Bhattacharyya A, Lahiry L, Mandal D, Sa G
Black tea induces tumor cell apoptosis by Bax translocation, loss in
mitochondrial transmembrane potential, cytochrome c release and caspase
activation. Int. J. Cancer 117:308-15, 2005
Mandal D, Bhattacharyya A, Lahiry L, Bhattacharyya S,
Sa G & Das T. Tumor-induced thymic involution via Inhibition of IL-7Ra
and its JAK-STAT signaling pathway: Protection by Black Tea. Int.
Pal S, Bhattacharya S, Choudhuri T, Datta GK, Das T & Sa G.
Amelioration of immune cell number depletion and potentiation of depressed
detoxification system of tumor-bearing mice by curcumin. Cancer
Detection Prevention, 29:470-8, 2005
Mandal D, Bhattacharyya A, Lahiry L, Sa G &
Das T. Failure in peripheral immuno-surveillance due to thymic
atrophy: Importance of thymocyte maturation and apoptosis in adult
tumor-bearer. Life Sci. 77:2703-16, 2005
Mandal D, Lahiry L, Bhattacharyya A, Chattopadhyay S, Siddiqi
M, Sa G & Das T. Black tea protects thymocytes in tumor-bearers by
differential regulation of intracellular ROS in tumor cells and thymocytes.
J. Environ. Toxicol. Pathol. Oncol. 24:91-104, 2005
Bandyopadhyay S, Bhattacharyya A, Mallick A, Sen AK,
Das T, Sa G, Bhattacharya DK & Mandal C. Over
expressed IgG2 antibodies against O-acetylated sialoglycoconjugates
incapable of proper effector functioning in childhood acute lymphoblastic
leukemia. Int. Immunol. 17:177-91, 2005
Sa G, Ganesan V, Bhar R & Roy Chowdhury A (2005) Is
occupational lead exposure detrimental to human spermatozoa? A question of
recent concern. JCMS 2, 105-110.
Sa G & Stacey DW. (2004) P27 expression is regulated by
separate signaling pathways, downstream of Ras, in each cell cycle phase.
Exp Cell Res 300, 427-439, 2004
Bhattacharyya A, Mandal D, Lahiry L, Sa G & Das T.
Black tea protects immunocytes from tumor-induced apoptosis
by changing Bcl-2/Bax ratio. Cancer Lett 209: 147-154,
Mandal D, Lahiry L, Bhattacharyya A, Bhattacharyya A, Sa G &
Das T. Pharmacotherapeutics of tea: Proposed strategies and pharmacological
studies. Int J Tea Sci 3: 261-272, 2004
Bhattacharyya A, Chattopadhyay S, Choudhury T, Banerjee A, Sa
Apoptogenic effects of black tea on Ehrlich's ascites carcinoma
cell. Carcinogenesis 24: 75-80, 2003
Bhattacharyya A, Sa G, Das T & Siddiqi M. Black tea-induced
cellular survival: Evidence for reduced toxicity and enhanced immunity in
mice under stress. Int J Tea Sci 2: 34-39, 2003
Sa G, Hitomi M, Harwalkar J, Stacey A, Chen G, & Stacey D.
Ras is active throughout the cell cycle, but is able to induce cyclin D1
only during G2 phase. Cell Cycle 1, 50-58, 2003 [with front
cover page citing the work along with a View and Commentaries (Cell
Cycle 1, 36-38, 2003)]
Ghosh S, Bhattacharyya S, Sirkar M, Sa G, Das T, Majumdar D,
Roy S & Majumdar S. Leishmania donovani suppresses activated protein 1 and
NF-kappaB activation in host macrophages via ceramide generation:
Involvement of extracellular signal-regulated kinase. Infect Immun
70: 6828-6838, 2002
Das T, Sa G, Chattopadhyay S & Ray PK. Protein A-induced
apoptosis of cancer cells is affected by soluble immune mediators.
Cancer Immunology Immunotherapy 51: 376-380, 2002
Choudhuri T, Pal S, Agwarwal ML,
Das T & Sa G. Curcumin induces apoptosis in human breast cancer
cells through p53-dependent Bax induction. FEBS Lett 512:
Das T, Sa
G, & Ray PK. Protein A-activated macrophages induce apoptosis in Ehrlich's
ascites carcinoma through a nitric oxide-dependent pathway. Apoptosis
7: 49-57, 2002
Pal S, Choudhuri T, Chattopadhyay S, Bhattacharya A, Datta
Das T &
Sa G. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites
carcinoma cells. Biochem Biophys Res Commun 288: 658-665, 2001
Das T, Sa G, Subbulakshmi V, Subramaniam S, Sen PC, Biswas S
Ray PK. Protein A-activated rat spleenic lymphocyte proliferation involves
tyrosine kinase - phospholipase C - protein kinase C pathway.
Immunopharmacol. Immunotoxicol. 22:
Ray PK, Das T, Sa G, Ghosh AK &
Chattopadhyay S. Protection of apoptotic cell death by Protein A.
Apoptosis 5: 509-514, 2000
Das T, Sa G & Ray PK.
of Protein A superantigen-induced signal transduction for proliferation of
mouse B cells.
Das T, Sa G, Sinha P
Induction of cell
proliferation and apoptosis: dependence on the dose of the inducer.
Biochem. Biophys. Res. Commun.
Ghosh AK, Jana S,
Das T, Sa
G, Mondal N & Ray PK. Protection by Protein A of apoptotic death caused by
anti-AIDS drug zidovudine. Biochem. Biophys. Res. Commun. 264:
Sinha P, Ghosh AK,
Das T, Sa
G & Ray PK. Protein A of S. aureus evokes Th1 type response in mice.
Immunol. Lett. 67: 157-165, 1999
Das T. Basic FGF
phospholipase A2, phospholipase C-g1 and phospholipase D through
distinguishable signaling mechanisms.
Ghosh AK, Sinha P,
Das T, Sa
G & Ray PK. S. aureus superantigen Protein A expand CD4+/CD19+/CD34+
cells in mice- a potential immunorestorer. Biochem. Biophys. Res.
Commun. 256: 142-146, 1999
Das T, Sa
G & Ray PK. Protein A induces NO production: Involvement of tyrosine kinase,
phospholipae C and Protein kinase C. Biochem. Biophys. Res. Commun.
250: 425-429, 1998
Murugesan G, Jaye M, Ivashenko Y & Fox PL. Activation of cytosolic
phospholipase A2 by basic fibroblast growth factor via a p42
mitogen-activated protein kinase-dependent
phosphorylation pathway in endothelial
cells. J Biol Chem 270, 2360-2300, 1995
Bandhopadhyay AK, Das T, Sa G & Mukherjea M. Relationship
between glycerol 3 phosphate dehydrogenase, fatty acid synthase and FABP of
developing human placenta. J Biosci 20, 141-150, 1995
& Fox PL. Basic fibroblast growth factor-stimulated endothelial cell
movement is mediated by a pertussis toxin-sensitive phospholipase A2
activity. J Biol Chem 269, 3219-3225, 1994
Fox PL, Sa G, Dobrowolski SF & Stacey DW.
regulation of endothelial cell motility by p21ras. Oncogene 9,
Murugesan G, Sa G & Fox PL.
density lipoprotein stimulates endothelial cell movement by a mechanism
distinct from basic fibroblast growth factor. Circulation Res
74, 1149-1156, 1994
Bandhopadhyay AK, Das T, Sa G & Mukherjea M. Effect of fatty
acid binding protein on cytosolic malate dehydrogenase of developing human
placenta. Indian J Experi Biol 32, 800-803, 1994.
Sa G and Fox PL. Basic fibroblast growth factor-mediated
migration and proliferation of endothelial cells are distinguished by
Fox PL, Chisolm GM, Murugesan G & Sa G. Regulation of
endothelial cell migration by plasma lipoproteins. Annu Biomed Engg
21, 1-31, 1993.
Das T & Mukherjea M. Characterization and binding properties of human fetal
lung fatty acid binding proteins. Mol Cell Biochem 129,
Das T & Mukherjea M. The evaluation of lung maturity by lecithin, L/S and
PG/PI ratios in human fetus. Med Sci Res 21, 365-366,
Das T, Sa G & Mukherjea M. Characterization of cardiac fatty
acid binding protein from human placenta: Comparison with placenta hepatic
proteins. Eur J Biochem 211, 725-730, 1993.
Ghosh PK, Das T, Sa G & Mukherjea M.
Gestational variation in the fluidity of human placental brush border
membrane: Assessed by lyposomal transfer study. Med Sci Res
20, 705-706, 1992
Mukhopadhyay D, Das T, Sa G, Ghosh PK & Mukherjea M.
Isolation of fatty acid binding protein from developing human fetal brain.
Med Sci Res 20, 641-642, 1992
Das T, Sa G, Bandhopadhyay AK & Mukherjea M. Relationship
between fatty acid binding proteins, acetyl CoA formation and fatty acid
synthesis in developing human placenta. J Biosci 16,
Chatterjee M, Das PK & Nandy A. Perception of biotechnology amongst Indian
biologists. Indian Biologist 28, 53-57, 1991
Chatterjee M, Sa G, Datta AG, Bhaduri AN, Das PK & Nandy A.
Perception of biotechnology amongst non-biologists in India.
Everymans Science 26, 48-50, 1991
Das T & Mukherjea M. Relationship between fatty acid synthesis, transport
and total lipid content during human fetal lung development. Indian J
Biochem Biophys 27, 43-47, 1990
Das T, Sa G, Ghosh PK, Mukhopadhyay D & Mukherjea M.
Isolation of fatty acid binding protein from human fetal intestine and
heart: Comparison with corresponding hepatic proteins. Med Sci Res
17, 985-986, 1989
Das T & Mukherjea M. Purification and characterization of fatty acid
binding protein from human fetal lung. Exp Lung Res 15,
Das T, Sa G & Mukherjea M. Human fetal liver fatty acid
binding proteins. Role on glucose 6
phosphate dehydrogenase activity. Biochim Biophys Acta
1002, 164-172, 1989
Das T, Sa G & Mukherjea M. Purification and characterization
of fatty acid binding protein from developing human placenta. Lipids
23, 528-533, 1988
Das T & Mukherjea M. Ontogenic profile and properties of glucose 6
phosphate dehydrogenase in human fetal tissues. Indian J Biochem
Biophys 23, 135-137, 1987
Book Chapter / Reviews etc.
Parton M, Das T, Sa G, Finke J, Eisen T, &
Tannenbaum C. Tumour Necrosis Factor - Misnomer and Therapeutic Target. In:
Targeted Therapy for Renal Cell Carcinoma (Ed: Dr. R Bukowski).
Springer Publishing Company, New York, NY. Chapter
19, 425-488, 2009
Chattopadhyay S, Saha B, Mandal D,
Sa G &
Das T. Black tea: A Review. In: Economic Crisis in Tea Industry:
Strategies for Scientific Management. (Ed: Dr. F. Rahman and Dr.
Peter Baker). ISTS Book 3 of the Book series Global Advances in Tea
Science. Studium Press LLC, Houston Texas, USA. Chapter 34, 2007
Sa G, Pal S & Choudhuri T. Curcumin: A
journey from spice to cancer
chemoprevention in Emerging Pollutants: Impact on Agriculture,
Environment and Health (Ed. De A and
Gupta S), Allied Publishers, India pp 139-153, 2006.
Das T, Sa G & Siddiqi M. Potential targets of tea
polyphenols in cancer prevention: significance in angiogenesis, metastasis
and apoptosis as well as in protection of host defense system. In:
of tea on human health
(Eds. J Weisberger, N K Jain and M Siddiqi) Cabi London, 76-90, 2006
Lahiry L, Mandal D, Bhattacharyya A, Sa G & Das T.
Cancer prevention by cancer regression and rejuvenation of host defense
system: Dual role of tea. In: Tea Therapeutics (Eds. B
Banerjee & TC Chaudhury) Science Publishers, INC., USA, UK, pp 89-112, 2005.
Ray PK, Das T & Sa G. (2001) How to activate
intrinsic stress resistance mechanisms to obtain therapeutic benefit. In:
Cell and Molecular Responses to Stress (Eds. Storey JM and
Storey KB) Elsevier Science, USA, Volume 2, 195-202.
Ray PK, Das T, Subbulakshmi V, Ghosh AK, Sa G, Sinha
P & Dasgupta P. Immunopharmacological modulation of host response to
increase therapeutic index of drugs. In Immunopharmacology: Strategies
for immunotherapy (Ed. S.N. Upadhyay) Narosa Press, India, 72-83,
Ray PK, Goenka S, Das T, Sa G, Sinha P & Srivastava
M. (1998) Role of nitric oxide in immune function and amelioration of
toxicity and carcinogenicity of drugs and
chemicals. In: Biological oxidants and anti-oxidants: Molecular
mechanisms and health effects. (Ed. L
Packer) AOCS Press, USA, Ch.7, 42-53.
1. Sa G & Das T. A process for producing therapeutically
active pure curcumin from Curcuma longa Linn. The gazette of
India, Part III, Section 2, August 30, 2003