Prof. Gaurisankar Sa, Ph.D. 

List of publications in reverse chronological order

A.     Peer reviewed journals

 1.        Chakraborty J, Banerjee S, Ray P, Hossain DMS, Bhattacharyya S, Adhikary A, Chattopadhyay S, Das T & Sa G. Gain of cellular adaptation due to prolong p53 impairment leads to functional switch-over from p53 to p73 during DNA damage in acute myeloid leukemia cells. J. Biol. Chem. (In press), 2010 

2.      Hossain DMS, Bhattacharyya S, Das T, & Sa G. Curcumin: The multi-targeted therapy for cancer regression. Frontiers in Biosciences (Invited submission), 2010


3.      Sa G, Das T, Roy P, Banerjee S & Chakraborty J. Oncogenes as molecular target for curcumin-induced cancer cell apoptosis. Prospective in Cytology & Genetics 14: (In press), 2010


4.      Mohanty S, Adhikary A, Chakrabarty S, Sa G & Das T. Operation ‘p53 Hunt’ to combat cancer: Theaflavins in action. Frontiers in Biosciences (Invited submission), 2010


5.      Das T, Sa G, Saha S, Mukherjee S, Mazumdar M & Mukherjee S. p53, a tumor suppressor at the crossroads of the oncogenic networks in cancer: Targeting the ‘guardian of the genome’.  Prospective in Cytology & Genetics 14: (In press), 2010


6.      Bhattacharyya S, Hossain D Md. S, Mohanty S, Sen GS, Chattopadhyay S, Banerjee S, Chakraborty J, Das K, Sarkar D, Das T & Sa G. Curcumin reverses T cell‐mediated adaptive immune dysfunctions in tumor‐bearing host. Cell. Mol. Immunol. 7: 306-315, 2010


7.      Lahiry L, Saha B, Chakraborty J, Adhikary A, Banerjee S, Das K, Sa G & Das T. Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. Carcinogenesis  31:259-68, 2010 

8.      Das T, Sa G, Saha B & Das K. Multifocal signal modulation therapy of cancer: Ancient weapon, modern targets. Mol. Cell. Biochem. 336:85–95, 2010

9.      Sa G, Das T, Banerjee S & Chakraborty J. Curcumin: From exotic spice to modern anticancer drug. AA J Med Sci. 3:21-37, 2010   

10.  Chattopadhyay S, Bhattacharyya S, Saha B, Chakrabarty J, Mohanty S, Hossain DMS, Banerjee S, Das K, Sa G & Das T. Tumor-shed PGE2 impairs IL2Rgc-signaling to inhibit CD4+ T cell survival: Regulation by theaflavins. PLoS One 4:e7382, 2009


11.  Chatterjee S, Mookerjee A, Mookerjee Basu J, Chakraborty P, Ganguly A,
Adhikary A, Mukhopadhyay D, Banerjee R, Ashraf M, Biswas J, Das PK, Sa G, Chatterjee M, Das T & Chaudhuri SK. CuNG, a novel copper complex, modulates drug resistant tumor associated macrohages to reprogram T cells to elicit anti-tumor response. PLoS One 4:e7048, 2009 

12.  Sa G, Das T, Moon C, Hilston CM, Rayman PA, Rini BI, Tannenbaum CS & Finke JH. GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the Apoptosis of Activated but not Resting T Cells. Cancer Res. 69:3095-104, 2009  

13.  Lahiry L, Saha B, Chakraborty J, Bhattacharyya S, Chattopadhyay S, Choudhuri T, Mandal D, Bhattacharyya A, Sa G & Das T. Contribution of p53-mediated transcription-dependent pathway in mammary epithelial carcinoma cell apoptosis by theaflavins. Apoptosis 13:771-81, 2008  

14.  Das T, Sa G, Paszkiewicz-Kozik E, Hilston C, Molto L, Rayman P, Biswas K, Kudo D, Bukowski RM, Finke JH & Tannenbaum C. Tumors Induce T Cell Apoptosis Through Receptor-Dependent and Receptor-Independent Pathways. J. Immunol. 180:4687-96, 2008 [Das T and Sa G both contributed equally to this paper] 

15.  Das T, Sa G, Hilston C, Kudo D, Rayman P, Biswas K, Molto L, Bukowski R, Rini B, Finke JH & Tannenbaum C. GM1 and TNFa, overexpressed in renal cell carcinoma, synergize to induce T cell apoptosis. Cancer Research 68:2014-23, 2008 [Das T and Sa G both contributed equally to this paper] 

16.  Sa G & Das T. Anti cancer effects of curcumin: cycle of life and death. Cell Div. 3:14, 2008                            

17.  Das T, Sa G, Chattopadhyay S & Saha B. Black tea: The Future Panacea for Cancer. AA J Med Sci. 1:70-83, 2008   

18.  Bhattacharyya A, Mandal D, Lahiry L, Bhattacharyya S, Chattopadhyay S, Ghosh UK, Sa G & Das T. Black Tea-Induced Amelioration of Hepatic Oxidative Stress through Antioxidative Activity in EAC-Bearing Mice. J Environ Pathol Toxicol Oncol. 26:245-54, 2007 

19.  Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T & Sa G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem. 282:15954-64, 2007 

20.  Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH, Tannenbum CS, Das T & Sa G. Tumor-induced oxidative stress perturbs NFkB activity augmenting TNFa-mediated T cell death: Protection by curcumin. Cancer Research. 67:362-70, 2007   

21.  Mandal D, Bhattacharyya S, Lahiry L, Chattopadhyay S, Sa G & Das T. Black tea-induced decrease in IL-10 and TGF-b of tumor cells promotes Th1/Tc1 response in tumor-bearer. Nutrition Cancer 58:213-21, 2007  

22.  Raval G, Biswas S, Rayman P, Biswas K, Sa G, Ghosh S, Thornton M, Hilston C, Das T, Bukowski R, Finke J & Tannenbaum CS.  TNF-α Induction of GM2 Expression on Renal Cell Carcinomas Promotes T cell Dysfunction. J Immunol. 178:6642-522, 2007  

23.  Dasgupta R, Saha I, Pal S, Bhattacharyya A, Sa G, Nag TC, Das T & Maiti BR. Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline. Toxicology 227:94-104, 2006  

24.  Biswas K, Richmond A , Rayman P, Biswas S, Thornton M, Sa G, Das T, Zhang R, Chahlavi A, Tannenbaum CS, Novick A, Bukowski R & Finke JH. GM2 Expression in renal cell carcinoma: Potential role in tumor-induced immune dysfunction. Cancer Research. 66:6816-25, 2006 

25.  Mookerjee A, Mookerjee Basu J, Dutta P, Majumder S, Bhattacharyya S, Biswas J, Pal S, Mukherjee P, Raha S, Baral RN, Das T, Efferth T, Sa G, Roy S & Choudhuri SK. Overcoming drug resistant cancer by a newly developed copper chelate through host protective cytokine mediated apoptosis. Clinical Cancer Research 12:4339-49, 2006  

26.  Naha N, Sa G & Roy Chowdhury A. Inorganic lead exposure in battery and paint factory: effect on human sperm structure and functional activity. J UOEH 28, 157-171, 2006 

27.  Choudhuri T, Pal S, Das T & Sa G. Curcumin selectively induces apoptosis in deregu­lated cyclin D1 expressed cells at G2 phase of cell cycle in a p53-dependent manner. J. Biol. Chem. 280:20059-68, 2005 [with front page cover citing the work]. 

28.  Sa G, Guo Y & Stacey DW. Regulation of S phase initiation by p27Kip1 in NIH3T3 cells. Cell Cycle 4, 618-627, 2005 [with front page cover citing the work] 

29.  Bhattacharyya A, Lahiry L, Mandal D, Sa G & Das T. Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation. Int. J. Cancer 117:308-15, 2005  

30.  Mandal D, Bhattacharyya A, Lahiry L, Bhattacharyya S, Sa G & Das T. Tumor-induced thymic involution via Inhibition of IL-7Ra and its JAK-STAT signaling pathway: Protection by Black Tea. Int. Immunopharmacol. 6:433-44, 2005  

31.  Pal S, Bhattacharya S, Choudhuri T, Datta GK, Das T & Sa G. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detection Prevention, 29:470-8, 2005  

32.  Mandal D, Bhattacharyya A, Lahiry L, Sa G & Das T. Failure in peripheral immuno-surveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor-bearer. Life Sci. 77:2703-16, 2005 

33.  Mandal D, Lahiry L, Bhattacharyya A, Chattopadhyay S, Siddiqi M, Sa G & Das T. Black tea protects thymocytes in tumor-bearers by differential regulation of intracellular ROS in tumor cells and thymocytes. J. Environ. Toxicol. Pathol. Oncol. 24:91-104, 2005 

34.  Bandyopadhyay S, Bhattacharyya A, Mallick A, Sen AK, Tripathi G, Das T, Sa G, Bhattacharya DK & Mandal C. Over expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia. Int. Immunol. 17:177-91, 2005 

35.  Naha N, Sa G, Ganesan V, Bhar R & Roy Chowdhury A (2005) Is occupational lead exposure detrimental to human spermatozoa? A question of recent concern. JCMS 2, 105-110. 

36.  Sa G & Stacey DW. (2004) P27 expression is regulated by separate signaling pathways, down­stream of Ras, in each cell cycle phase. Exp Cell Res 300, 427-439, 2004 

37.  Bhattacharyya A, Mandal D, Lahiry L, Sa G & Das T. Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Lett 209: 147-154, 2004  

38.  Mandal D, Lahiry L, Bhattacharyya A, Bhattacharyya A, Sa G & Das T.  Pharmacotherapeutics of tea: Proposed strategies and pharmacological studies. Int J Tea Sci 3: 261-272, 2004  

39.  Bhattacharyya A, Chattopadhyay S, Choudhury T, Banerjee A, Sa G & Das T. Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Carcinogenesis 24: 75-80, 2003  

40.  Bhattacharyya A, Sa G, Das T & Siddiqi M. Black tea-induced cellular survival: Evidence for reduced toxicity and enhanced immunity in mice under stress. Int J Tea Sci 2: 34-39, 2003  

41.  Sa G, Hitomi M, Harwalkar J, Stacey A, Chen G, & Stacey D. Ras is active through­out the cell cycle, but is able to induce cyclin D1 only during G2 phase. Cell Cycle 1, 50-58, 2003 [with front cover page citing the work along with a View and Commentaries (Cell Cycle 1, 36-38, 2003)]   

42.  Ghosh S, Bhattacharyya S, Sirkar M, Sa G, Das T, Majumdar D, Roy S & Majumdar S. Leishmania donovani suppresses activated protein 1 and NF-kappaB activation in host macrophages via ceramide generation: Involvement of extracellular signal-regulated kinase. Infect Immun 70: 6828-6838, 2002  

43.  Das T, Sa G, Chattopadhyay S & Ray PK. Protein A-induced apoptosis of cancer cells is affected by soluble immune mediators. Cancer Immunology Immunotherapy 51: 376-380, 2002 

44.  Choudhuri T, Pal S, Agwarwal ML, Das T & Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett 512: 334-340, 2002  

45.  Chattopadhyay S, Das T, Sa G, & Ray PK. Protein A-activated macrophages induce apoptosis in Ehrlich's ascites carcinoma through a nitric oxide-dependent pathway. Apoptosis 7: 49-57, 2002 

46.  Pal S, Choudhuri T, Chattopadhyay S, Bhattacharya A, Datta GK, Das T & Sa G. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem Biophys Res Commun 288: 658-665, 2001  

47.  Das T, Sa G, Subbulakshmi V, Subramaniam S, Sen PC, Biswas S & Ray PK. Protein A-acti­vated rat spleenic lymphocyte proliferation involves tyrosine kinase - phospholipase C - protein kinase C pathway. Immunopharmacol. Immunotoxicol. 22: 75-90, 2000  

48.  Ray PK, Das T, Sa G, Ghosh AK & Chattopadhyay S. Protec­tion of apoptotic cell death by Protein A. Apoptosis 5: 509-514, 2000  

49.  Das T, Sa G & Ray PK. Mechanisms of Protein A superantigen-induced signal transduction for proliferation of mouse B cells. Immunol. Lett. 70: 43-51, 1999 

50.  Das T, Sa G, Sinha P & Ray PK. Induction of cell proliferation and apoptosis: dependence on the dose of the inducer. Biochem. Biophys. Res. Commun. 260: 105-110, 1999 

51.  Ghosh AK, Jana S, Das T, Sa G, Mondal N & Ray PK. Protection by Protein A of apoptotic death caused by anti-AIDS drug zidovudine. Biochem. Biophys. Res. Commun. 264: 601-604, 1999  

52.  Sinha P, Ghosh AK, Das T, Sa G & Ray PK. Protein A of S. aureus evokes Th1 type response in mice. Immunol. Lett. 67: 157-165, 1999  

53.       Sa G & Das T. Basic FGF stimulates phospholipase A2, phospholipase C-g1 and phos­pholipase D through distinguishable signaling mechanisms. Mol. Cell. Biochem. 198: 19-30, 1999   

54.  Ghosh AK, Sinha P, Das T, Sa G & Ray PK. S. aureus super­antigen Protein A expand CD4+/CD19+/CD34+ cells in mice- a potential immunorestorer. Biochem. Biophys. Res. Commun. 256: 142-146, 1999 

55.  Goenka S, Das T, Sa G & Ray PK. Protein A induces NO produc­tion: Involvement of tyrosine kinase, phospholipae C and Protein kinase C. Biochem. Biophys. Res. Commun. 250: 425-429, 1998 

56.  Sa G, Murugesan G, Jaye M, Ivashenko Y & Fox PL. Activation of cytosolic phos­pho­lipase A2 by basic fibroblast growth factor via a p42 mito­gen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J Biol Chem 270, 2360-2300, 1995 

57.  Bandhopadhyay AK, Das T, Sa G & Mukherjea M. Relationship between glycerol 3 phos­phate dehydrogenase, fatty acid synthase and FABP of developing human placenta. J Biosci 20, 141-150, 1995 

58.  Sa G & Fox PL. Basic fibroblast growth factor-stimulated endothelial cell move­ment is mediated by a pertussis toxin-sensitive phospholipase A2 activity. J Biol Chem 269, 3219-3225, 1994  

59.  Fox PL, Sa G, Dobrowolski SF & Stacey DW. The regulation of endothelial cell motility by p21ras. Oncogene 9, 3519-3526, 1994.   

60.  Murugesan G, Sa G & Fox PL. High density lipoprotein stimu­lates endothelial cell movement by a mechanism distinct from basic fibroblast growth factor. Circulation Res 74, 1149-1156, 1994 

61.  Bandhopadhyay AK, Das T, Sa G & Mukherjea M. Effect of fatty acid bind­ing protein on cytosolic malate dehydrogenase of developing human placenta. Indian J Experi Biol 32, 800-803, 1994.  

62.  Sa G and Fox PL. Basic fibroblast growth factor-mediated migration and proliferation of endothelial cells are distinguished by pertussis toxin. FASEB J, 7, A1-A2, 1993 

63.  Fox PL, Chisolm GM, Murugesan G & Sa G. Regulation of endothelial cell migra­tion by plasma lipoproteins. Annu Biomed Engg 21, 1-31, 1993.  

64.  Sa G, Das T & Mukherjea M. Characterization and binding properties of human fetal lung fatty acid binding proteins. Mol Cell Biochem 129, 67-75, 1993.  

65.  Sa G, Das T & Mukherjea M. The evaluation of lung maturity by leci­thin, L/S and PG/PI ratios in human fetus. Med Sci Res 21, 365-366, 1993  

66.  Das T, Sa G & Mukherjea M. Characterization of cardiac fatty acid binding protein from human placenta: Comparison with placenta hepatic proteins. Eur J Biochem 211, 725-730, 1993.  

67.  Ghosh PK, Das T, Sa G & Mukherjea M. Gestational variation in the fluid­ity of human placental brush border membrane: Assessed by lyposomal transfer study.  Med Sci Res 20, 705-706, 1992  

68.  Mukhopadhyay D, Das T, Sa G, Ghosh PK & Mukherjea M. Isolation of fatty acid binding protein from developing human fetal brain. Med Sci Res 20, 641-642, 1992  

69.  Das T, Sa G, Bandhopadhyay AK & Mukherjea M. Relationship between fatty acid bind­ing proteins, acetyl CoA formation and fatty acid synthesis in deve­loping human placenta. J Biosci 16, 235-242, 1991 

70.  Sa G, Chatterjee M, Das PK & Nandy A. Perception of biotechnology amongst Indian biologists. Indian Biologist 28, 53-57, 1991 

71.  Chatterjee M, Sa G, Datta AG, Bhaduri AN, Das PK & Nandy A. Perception of biotech­nology amongst non-biologists in India. Everymans Science 26, 48-50, 1991  

72.  Sa G, Das T & Mukherjea M. Relationship between fatty acid synthesis, trans­port and total lipid content during human fetal lung development. Indian J Biochem Biophys 27, 43-47, 1990  

73.  Das T, Sa G, Ghosh PK, Mukhopadhyay D & Mukherjea M. Isolation of fatty acid bind­ing protein from human fetal intestine and heart: Comparison with corre­sponding hepatic proteins. Med Sci Res 17, 985-986, 1989  

74.  Sa G, Das T & Mukherjea M. Purification and characterization of fatty acid bind­ing protein from human fetal lung. Exp Lung Res 15, 619-632, 1989 

75.  Das T, Sa G & Mukherjea M. Human fetal liver fatty acid binding proteins. Role on glucose 6 phosphate dehydrogenase activity. Biochim Biophys Acta 1002, 164-172, 1989 

76.  Das T, Sa G & Mukherjea M. Purification and characterization of fatty acid bind­ing protein from developing human placenta. Lipids 23, 528-533, 1988 

77.  Sa G, Das T & Mukherjea M. Ontogenic profile and properties of glucose 6 phos­phate dehydrogenase in human fetal tissues. Indian J Biochem Biophys 23, 135-137, 1987 

B.   Book Chapter / Reviews etc. 

1.        Parton M, Das T, Sa G, Finke J, Eisen T, & Tannenbaum C. Tumour Necrosis Factor - Misnomer and Therapeutic Target. In: Targeted Therapy for Renal Cell Carcinoma (Ed: Dr. R Bukowski). Springer Publishing Company, New York, NY. Chapter 19, 425-488, 2009 

2.         Chattopadhyay S, Saha B, Mandal D, Sa G & Das T. Black tea: A Review. In: Economic Crisis in Tea Industry: Strategies for Scientific Management.  (Ed: Dr. F. Rahman and Dr. Peter Baker). ISTS Book 3 of the Book series Global Advances in Tea Science. Studium Press LLC, Houston Texas, USA. Chapter 34, 2007 

3.         Sa G, Pal S & Choudhuri T. Curcumin: A journey from spice to cancer chemopre­vention in Emerging Pollutants: Impact on Agriculture, Environment and Health (Ed. De A and Gupta S), Allied Publishers, India pp 139-153, 2006. 

4.         Das T, Sa G & Siddiqi M. Potential targets of tea polyphenols in cancer preven­tion: significance in angiogenesis, metastasis and apoptosis as well as in protection of host defense system. In: Protective effects of tea on human health (Eds. J Weisberger, N K Jain and M Siddiqi) Cabi London, 76-90, 2006 

5.         Lahiry L, Mandal D, Bhattacharyya A, Sa G & Das T. Cancer prevention by cancer regression and rejuvenation of host defense system: Dual role of tea. In: Tea Therapeutics (Eds. B Banerjee & TC Chaudhury) Science Publishers, INC., USA, UK, pp 89-112, 2005. 

6.         Ray PK, Das T & Sa G. (2001) How to activate intrinsic stress resistance mechanisms to obtain thera­peutic benefit.  In: Cell and Molecular Responses to Stress (Eds. Storey JM and Storey KB) Elsevier Science, USA, Volume 2, 195-202. 

7.         Ray PK, Das T, Subbulakshmi V, Ghosh AK, Sa G, Sinha P & Dasgupta P. Immuno­pharmacological modulation of host response to increase therapeutic index of drugs. In Immunopharmacology: Strategies for immunotherapy (Ed. S.N. Upadhyay) Narosa Press, India, 72-83, 1999. 

8.         Ray PK, Goenka S, Das T, Sa G, Sinha P & Srivastava M. (1998) Role of nitric oxide in immune func­tion and amelioration of toxicity and carcinogenicity of drugs and chemicals. In: Biological oxidants and anti-oxidants: Molecular mechanisms and health effects. (Ed. L Packer) AOCS Press, USA, Ch.7, 42-53. 


1.   Sa G & Das T. A process for producing therapeutically active pure curcumin from Curcuma longa Linn. The gazette of India, Part III, Section 2, August 30, 2003