Kaushik Biswas, PhD

Associate Professor
Division of Molecular Medicine
I.I.C.B, Jadavpur University (2001)

Tel: 91-33-2569-3217
Fax:  91-33-2355-3886


Website : www.jcbose.ac.in/kaushik


Research interest

Understanding the mechanism of tumorigenesis specifically focussing on the role of glycolipids in tumor growth, progression and metastasis.


Specific Research Focus :        

  • How tumor derived Gangliosides modulate tumor growth, progression and metastasis ?

  • Targeted Genome Editing tools (TALEN and CRISPR) to study mechanisms in carcinogenesis, focusing primary on unknown functions of genes in cancer

  • Epigenetic regulation of ganglioside synthase genes in cancer

  • Screening and identification of compounds from natural sources as potential therapeutics against cancer

  • Mechanism of tumor induced immune suppression


We have taken an all round approach towards understanding the basis of aberrant ganglioside expression in various tumors as  well as studying the consequence of such an abnormal expression in carcinogenesis. Gene silencing as well as molecular cloning and over-expression strategies have been utilized to establish the potential role  of tumor derived glycosphingolipids in migration as well as invasion of tumor cells. Gene expression profiling suggests a large number of differentially regulated gene sets (DRGs) in response to GM2-synthase knockdown and mechanistic studies reveal a critical role of the integrin signaling pathway to be involved in GM2 mediated tumor cell migration. With an aim to translate these in vitro findings in vivo, targeted genome editing technology by TALEN is used to define the functional role of GM2 in tumorigenesis. Studies indicate that GM2 is involved in epithelial-mesenchymal transition (EMT) by promoting anoikis resistance in tumors. Studies are under way to elucidate the mechanism of GM2 mediated EMT. Finally, we have initiated a study to find out the basis of over-expression of several ganglioside synthase genes in cancer, currently focusing on the regulation of GM2-synthase gene. Preliminary data suggests that there may be a plausible epigenetic role in the regulation of GM2-synthase gene in cancer. On a different note, we have very recently undertaken a collaborative study, to screen and identify potential anti-inflammatory compounds from natural sources, those by virtue of being anti-inflammatory may be able to protect against chronic inflammation induced disease pathogenesis, like cancer.


Collaborator :

  • Dr. Uday Bandyopadhyay, Principal Scientist, Infectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata

  • James H. Finke, PhD., Staff Scientist, Department of Immunology, Lerner Research Institute, Cleveland Clinic, OH, USA

  • Dr. Zhumur Ghosh, Assistant Professor, BioInformatics Division, Bose Institute, Kolkata.

  • Dr. Rupak Mukhopadhyay, Assistant Professor, Tezpur University.

  • Dr. Anup K. Misra, Associate Professor, Division of Molecular Medicine, Bose Institute, Kolkata

  • Dr. Ajit Bikram Datta, Associate Professor, Biochemistry Department, Bose Institute, Kolkata

List of Publications :

  1. Barun Mahata, Soumika Biswas, Patricia Rayman, Ali Chahlavi, Jennifer Ko, Ashish Bhattacharjee, Yu-Teh Li, Yuntao Li, Tanya Das, Gaurisankar Sa, Baisakhi Raychaudhuri, Michael A. Vogelbaum, Charles Tannenbaum, James H. Finke and Kaushik Biswas*, "GBM derived gangliosides induce T cell apoptosis through activation of the caspase cascade involving both the extrinsic and the intrinsic pathway." PLOS ONE, July 30, 2015.

  2. Barun Mahata, Avisek Banerjee, Manjari Kundu, Uday Bandyopadhyay and Kaushik Biswas*, "TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells." Scientific Reports, 5, 9048, 2015.

  3. Pravat Kumar Parida, Abhijit Sau, Tamashree Ghosh, Kuladip Jana,* Kaushik Biswas,* Sanghamitra Raha and Anup Kumar Misra*, "Synthesis and evaluation of triazole linked glycosylated 18β-glycyrrhetinic acid derivatives as anticancer agents." Bioorganic & Medicinal Chemistry Letters, 24, 3865-3868, 2014.

  4. Biswas, S., Biswas, K., Richmond, A., Ko, J. et. al.  “Elevated levels of select gangliosides in T cells from Renal Cell Carcinoma patients is associated with T-cell dysfunction.” J. Immunol., 183, 5050-5058, 2009.

  5. Raval, G., Biswas, S., Rayman, P., Biswas, K., et. al. “TNF-a Induction of GM2 Expression on Renal Cell Carcinomas Promotes T cell Dysfunction.” J.Immunol., 178, 6642-6652, 2007.

  6. Biswas, K., Richmond, A., Rayman, P., Biswas, S., et. al.  “GM2 Expression in Renal Cell Carcinoma : Potential Role in Tumor Induced T cell Dysfunction.” Cancer Res., 66, 6816-6825, 2006.

  7. Biswas, K., Bandyopadhyay, U., Chattopadhyay, I., Varadaraj, A. et. al.  “A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.” J.Biol.Chem., 278, 10993-11001, 2003.

  8. Biswas, K., Chatterjee, I., Banerjee, R.K. and Bandyopadhyay, U., “Biological activity and medicinal uses of Neem ( Azadirachta indica ).” Curr. Sci., 82, 1336-1345, 2002.