K .P. Das
Senior Professor, Chemistry
PhD: Jadavpur University (1982)

Research interest

 ·              Structural aspects of interaction of substrate proteins with molecular chaperones

·              Structural mechanism of regulation of the molecular chaperone function by small molecules

·              Molecular interactions in amyloid fibril formation

·              Protein nano-particle interaction

Selected publications

1.      Srabani Karmakar and K. P. Das, ”Stabilization of oligomeric structure of a-crystallin by 

          Zn+2 through intersubunit bridging”, Biopolymers, 95(2), 105-116 (2011). 

2.      A. Biswas and K. P. Das, “Zn⁺² Enhances molecular chaperone function and stability of a-crystallin”, Biochemistry, 47, 804-816 (2008).                                             

3.      M. Kundu, P. C. Sen and K. P. Das, “Structure, stability and chaperone function of a-crystallin: role of the N-terminal region”, Biopolymers, 86(3), 177-192 (2007).

4.      A. Biswas and K. P. Das, “Differential recognition of natural and non-natural substrate by molecular chaperone a-crystallin - a subunit exchange study”. Biopolymers, 85(2), 189-197 (2007).  

5.      Biswas, A. & Das, K. P., “Role of ATP on the interaction of a-crystallin with substrates and its implications for its molecular chaperone function”, J. Biol. Chem., 279, 42648-42657 (2004).             

6.      Saha, S. & Das, K. P., “Relationship between chaperone activity and oligomeric size of recombinant aA- and aB-crystallin: a tryptic digestion study”, Proteins, 57(3), 610-617 (2004).                     

7.      T. Manna, T. Sarkar, A. Poddar, M. Roychowdhury, K. P. Das, and B. Bhattacharyya, “Chaperone-like activity of tubulin: Binding and reactivation of unfolded substrate enzymes”, J. Biol. Chem., 276, 39742-39747 (2001).                                                       

8.      C. Bhattacharjee and K. P. Das, “Thermal unfolding and refolding of b-lactoglobulin - an intrinsic and extrinsic fluorescence study”, Eur. J. Biochem., 267, 3957-3964 (2000).                                                                                                                      

9.      K. P. Das, Choo-Smith, L. P., M. J. Petrash and W. K. Surewicz, “Insight into the secondary structure of non-native proteins bound to a molecular chaperone alpha-crystallin: an isotope edited infrared spectroscopic study”, J. Biol. Chem., 274(47), 33209-33212 (1999).                                                                                                                       

10.     J. Bhattacharyya and K. P. Das, “Molecular chaperone-like properties of an unfolded protein: a_s-casein”, J. Biol. Chem.,  274, 15505-15509 (1999).             

11.     S. Guha, T. K. Manna, K. P. Das and B. Bhattacharyya, “Chaperone-like activity of tubulin”, J. Biol. Chem., 273, 30077-30080 (1998). 

12.     K. P. Das and W. K. Surewicz, “Temperature induced exposure of hydrophobic surfaces and its effect on the chaperone activity of a-crystallin”, FEBS Lett., 369, 321-325 (1995). 

To see the list of full publications, click here.