Manikuntala Kundu
Senior Professor, Chemistry
PhD(Biochemistry): University of Calcutta(1988)

 

Research interests

        i.            Dissecting host-pathogen interactions with reference to Helicobacter pylori and pathogenic mycobacteria.

      ii.            Understanding the stress response in mycobacteria with special reference to  extracytoplasmic function sigma factors and two-component systems

    iii.            Analyzing the role of positive feedback in phenotypic heterogeneity of stress response genes in mycobacteria.

    iv.            Understanding bacterial efflux pumps and their role in drug resistance.

Further interests at : http://www.boseinst.ernet.in/sysbio/

Selected publications

 1. Dasgupta, A., Sureka, K., Mitra, D.,  Saha, B., Sanyal, S.,  Das,  A.K., Chakrabarti, P., Jackson, M., Gicquel, B., Kundu, M., and Basu, J.  (2010) An oligopeptide tansporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages. PLoS ONE  5 :  e12225 

2. Barik, S., Sureka, K., Basu, J., and Kundu, M. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. (2009) Mol. Microbiol. doi.: 10.1111/j/1365-2958.2009.07008x 

3. Sureka, K., Ghosh, B., Dasgupta, A., Basu, J., Kundu, M. and Bose, I. Positive feedback and noise activate the stringent response regulator Rel in mycobacteria. (2008) PLoS One, 3: e1771

4. Kundu, M., Pathak, S.K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S.,  Noguchi, T.,  Takeda, K.,  Ichijo, H., Thien,  C.B.F.,. Langdon, W.Y. and  and Basu, J. A tumor necrosis factor- and c-Cbl-dependent FLIP_S degradation pathway and its role in Mycobacterium tuberculosis-induced macrophage apoptosis   (2009) Nature Immunol. 10, 918-925 

5. Basu, S., Pathak, S.K., Chatterjee, G., Pathak, S., Basu, J., Kundu, M. Helicobacter pylori protein HP0175 transactivates EGFR through TLR4 in gastric epithelial cells. (2008) J. Biol. Chem. 283, 32369-32376 

6. Sureka, K., Dey, S., Datta, P., Singh, A.K., Dasgupta, A., Rodrigue, S., Basu, J., Kundu, M. Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria. (2007) Mol. Microbiol. 65, 261-276 

7. Pathak, S.K.,  Bhattacharyya, A., Basu, S., Banerjee, A., Basu, J., and Kundu, M.  TLR4-dependent NF-kappa B activation and mitogen- and stress-activated proteins kinase 1-triggered phosphorylation events are central to Helicobacter pylori peptidyl prolyl cis-, trans- isomerase (HP0175)-mediated induction of IL-6 release from macrophages. (2006) J. Immunol. 177, 7950-7958 

8. Pathak,  S.K., Basu, S., Basu,  K.K., Banerjee, A., Pathak,  S., Bhattacharyya, A., Kaisho, T., Kundu,  M., and Basu,  J. Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. (2007) Nat Immunol. 8, 610-618  

9. Basak, C.,  Pathak, S.K.,  Bhattacharyya, A.,  Pathak, S.,  Basu, J.  and Kundu, M.  The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a Toll-like receptor 4 and apoptosis signal-regulating kinase 1(ASK1)-dependent manner. (2005) J. Immunol., 174, 5672-5680 

10. Basak, C., Pathak, S., Bhattacharyya, A., Mandal, D.,  Pathak, S.,  and Kundu, M.  NF-kB- and C/EBPb-driven interleukin-1b gene expression and PAK1-mediated caspase 1 activation play essential roles in interleukin-1b release from Helicobacter  pylori lipopolysaccharide (LPS)-stimulated macrophages.  (2005) J. Biol. Chem. 280, 4279-4288

11. Basu, S.,  Pathak,  S.K., Banerjee, A., Pathak, S.,  Bhattacharyya, A.,  Yang, Z., Talarico, S., Kundu, M. and Basu, J. Execution of macrophage apoptosis by PE_PGRS33 of Mycobacterium tuberculosis is mediated by Toll-like receptor 2-dependent release of tumor necrosis factor-α  (2007) J. Biol. Chem.  282, 1039–1050

12. Bhattacharyya, A., Pathak, S., Basak, C., Law, S., Kundu, M. and Basu, J. (2003) Execution of macrophage apoptosis by Mycobacterium avium through apoptosis signal-regulating kinase 1/p38 mitogen-activated kinase signaling and caspase 8 activation. J. Biol. Chem. 278, 26517-26525

 Full list of publications

Contact:

E-mail: manikuntala.kundu@gmail.com; manikuntala.vsnl.net; mani@bosemain.boseinst.ac.in
Phone: 033 23031153 (office)
Fax: 033 23506790