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Division of Molecular Medicine
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Molecular
Medicine Division of Bose Institute has been created in January 2008
following the recommendation of the Scientific Advisory Committee which was
subsequently approved by Bose Institute Council. The Division has been
created with the merger of scientists from Animal Physiology, Chemistry,
Immuno-technology and Microbiology with a broad but specific objectives of
studying molecules related to health and diseases and manipulating those
molecules to improve diagnosis, prevention and treatment of diseases like
Cancer, Immunosuppression, Diabetes, Cardiovascular problems, Leishmaniasis,
Tuberculosis etc.
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Parimal C. Sen,
FNASc, F.A.Sc.T.
Professor
Division of Molecular Medicine (formerly
Professor of Chemistry)
Ph.D.:
University
of Calcutta (1977)
Head
Tel: 91-33-2569-3222
Fax: 91-33-2355-3886
E-mail:
parimal@bic.boseinst.ernet.in
parimalsen.boseinst@gmail.com
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Structure-function
relationship of ion-transporting enzymes and protein kinases
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Modulation of
ion-transporting enzymes by drugs, endogenous regulators and protein
kinase(s)
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Development of
synthetic anti-cancer drug
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Development of
protein based contraceptive drug
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Arun K Ray, Ph.D
Professor
Division
of Molecular Medicine (formerly Professor of Animal Physiology)
Ph.D.:
(Physiology)
University
of Calcutta (1974)
Tel: 91-33-2569-3256
Fax: 91-33-2355-3886
E-mail:
akray@bic.boseinst.ernet.in
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Thyroid hormone- mammalian brain interactio
- Improved
productivity in ediable fish
- Estradiol-17-beta
in silk production
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Parames C. Sil, Ph.D.
Professor
Division
of Molecular Medicine
Ph.D.:
University of Calcutta (1990)
Tel: 91-33-2569-3243
Fax: 91-33-2355-3886
Email:
parames@bosemain.boseinst.ac.in
parames@bic.boseinst.ernet.in
parames_95@yahoo.co.in
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Subrata Majumder, Ph.D.
Professor
Division of
Molecular Medicine
(formerly Department of Microbiology)
Ph.D.: (Biochemistry) University of
Calcutta (1986)
Tel: 91-33-2569-3230
Fax: 91-33-2355-3886
E-mail:
subrata@bic.boseinst.ernet.in
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Signal
transduction mechanism during host pathogen interaction
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Immunomodulatory role of glycolipid and Mw during visceral leishmaniasis
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T
regulatory cell function during infection
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Gaurisankar Sa, Ph.D.
Professor
Division of Molecular Medicine
Ph.D.:
(Biochemistry) University of Calcutta (1990)
Tel: 91-33-2569-3258
Fax: 91-33-2355-3886
E-mail:
gauri@bic.boseinst.ernet.in
gaurisankarsa@yahoo.com
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Mechanisms of cell
cycle regulation
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Role of oncogenic p21Ras in cancer progression
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Targeted alteration of signaling molecules to induce
apoptosis
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Development of anti-cancer drug from natural sources
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Mechanisms of
tumor-induced immuno-suppression
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Tanya Das, Ph.D.
Professor
Division of Molecular Medicine
Ph.D.: (Biochemistry)
University of
Calcutta (1989)
Tel: 91-33-2569-3257
Fax: 91-33-2355-3886
E-mail:
tanya@bic.boseinst.ernet.in
das_tanya@yahoo.com
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Development of selective
anti-cancer drug from natural sources
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Induction of tumor
cell apoptosis and retardation of metastasis
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Inhibition of tumor
angiogenesis
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Mechanisms of
cancer-induced immunosuppression
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Gene therapy for the management of cancer
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Nripendranath Mandal, Ph.D.
Associate Professor
Division of Molecular Medicine
Ph.D.:
University
of Calcutta (1990)
Tel: 91-33-2569-3285
Fax: 91-33-2355-3886
E-mail:
nripen@bic.boseinst.ernet.in
drnmandal@gmail.com
Development of various DNA/RNA markers in giant black tiger shrimp (Penaeus monodon) to identify the White spot syndrome virus (WSSV) resistant population of Penaeus monodon, and at the same time understand the molecular pathogenesis of white spot disease in shrimp
Development of scientific evidences for Indian system of traditional medicine, by isolation and characterization of active principles from medicinal herbs, along with multi-dimensional determination of their bio-activities for the potentials of antioxidant, anticancer, anti-inflammatory, anti-diabetic etc.
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Mahadeb Pal, Ph.D.
Associate Professor
Division of Molecular Medicine
Ph.D.: University
of Calcutta (1994)
Tel: 91-33-2569-3256
Fax: 91-33-2355-3886
E-mail:
mahadeb@bic.boseinst.ernet.in
palmahadeb@gmail.com
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Understanding the
molecular mechanisms of rapid transcriptional activation of stress
induced genes in mammalian cells.
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Screening of
Indian medicinal plant extracts for isolation of anti-cancer
therapeutics with special interests in finding modulators of
cellular
i) Heat
Shock Response pathway, and
ii) Toll Like
Receptor (TLR) signaling pathways
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Anup Kumar Misra, Ph.D.
Associate Professor
Division of Molecular Medicine
Ph.D.:
Indian Association for the Cultivation of Science (IACS), Calcutta, (Jadavpur University) 1997.
Tel: 91-33-2569-3240
Fax: 91-33-2355-3886
E-mail:
akmisra69@gmail.com
anup@bic.boseinst.ernet.in
Main research interest is to develop synthetic strategies for the synthesis of complex saccharide molecules of biological interest and their glycoconjugates to use them in the immunochemical studies towards the preparation of anti-microbial agents.
The group is also engaged in the design and synthesis of medicinally important small molecules (e.g. anticancer agents, antioxidantsis and enzyme inhibitors) and their bioevaluation in a collaborative program
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Atin K. Mandal, Ph.D.
Assistant Professor
Division of Molecular Medicine
Ph.D.:
Bose
Institute, Jadavpur University (2000)
Tel: 91-33-2569-3237
Fax: 91-33-2355-3886
E-mail:
mandalak@bic.boseinst.ernet.in
atink99@yahoo.com
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Protein quality control is
an essential cellular process that maintains protein homeostasis or
proteostasis. Maintaining proper balance between folding and degradation
of misfolded proteins is critical for cell survival. Molecular
chaperones facilitate polypeptide folding by protecting newly
synthesized or misfolded proteins against aggregation. They also promote
degradation of unfolded or misfolded proteins by the
ubiquitin-proteasome pathway. This quality control process plays a vital
role in several pathophysiological conditions including cancer, diabetes
and late-onset neurological diseases. My focus of research is to
understand the mechanism of cellular protein quality control.
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Kaushik Biswas, PhD
Asstt. Professor
Division of Molecular Medicine
Ph.D:
I.I.C.B, Jadavpur University (2001)
Tel: 91-33-2569-3217
Fax: 91-33-2355-3886
E-mail:
kbiswas_1@yahoo.com
kaushik@bic.boseinst.ernet.in
Elicitation of an active immune response in
response to an invading tumor has been well documented. However, in majority
of cases this kind of immune response, characterized by tumor infiltrating
lymphocytes (TILs), eventually becomes ineffective in either arresting the
growth of the tumor or in eradicating the tumor. This is because the tumor
cells have developed strategies and mechanisms to make the immune cells
dysfunctional. One of these mechanisms is through elaboration of tumor
derived products like glycosphingolipids. Our research will aim in not only
understanding the mechanism through which these tumor cells render the
immune system dysfunctional (focusing mostly on defective T cell signaling)
but also try to understand how some of the tumor derived products (like
glycosphingolipids) help the tumor cells themselves to cause increased
growth and migration and eventually lead to increased metastatic potential
and aggressiveness.
The other focus of the lab will be aimed in
understanding if and how chronic inflammation in many disease process
(focusing mostly on chronic inflammation in gastric pathogenesis) may lead
to carcinogenesis. In this aspect, research will primarily focus on
understanding the signaling events that lead to chronic inflammation induced
carcinogenesis using available model systems.
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Dr. Kuladip Jana
PhD
Scientist-"C"
Division of Molecular Medicine
Ph.D:
Vidyasagar University (2004)
Tel: 91-33-2569-3322
Fax: 91-33-2355-3886
E-mail: kuladip@bic.boseinst.ernet.in/
kuladip_jana@yahoo.com/
kuladip.jana@gmail.com
One major research focus is on the molecular regulation of Leydig cell
steroidogenic function and germ cell DNA damage/repair during aging; and in
particular on the role oxidative stress resulting from increased production
of reactive oxygen species and decreases in cellular antioxidant defences. A
second research focus on the germ line stem cells that ultimately give rise
to adult germ cells and Leydig cells, and on the issue of whether and how
stem cells age. A third focus is on the regulation of mammalian
spermatogenesis and its translation to male infertility and contraception.
Finally, we are examining the effect of fetal/adult exposure to xenobiotics
on steroidogenic functions later in life.
Molecular Mechanisms of Germ-line Stem Cell (GSC) Regulation, Self Renewal
and Differentiations.
Is GSC Aging due to Intrinsic Aging or Niche Aging: Identification and
Mechanism of Action?
Natural Flavonoids & Stilbenes Induced Death/Apoptosis in Cervical and
Breast Cancer Cells: Role of β- Catenin and Wnt Signalling.
Molecular Signalling of Germ cell and Leydig cell Apoptosis by Xenobiotics.
Ageing Associated Testicular Gametogenic & Steroidogenic Disorders with StAR
Gene Expression.
Identification of the Link Between Polycystic Ovary Syndrome and Both Type 1
and Type 2 Diabetes Mellitus:
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Other Staff Members |
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Research Fellows |
