Parames C. Sil

Professor: Division of Molecular Medicine
PhD: Calcutta University (1990)

  

Main objectives

  • Research in our laboratory encompasses several major areas of organ pathophysiology. Dysfunction in organs like liver, kidney, heart, etc. are in our focus and emphasis is placed upon:
  • Drug and chemical-induced mechanisms of cell injury and cell death in multiple vital target organs both in vivo and in vitro
  • Studies on the signal transduction mechanism of cell death and survival in organ pathophysiology.
  • Unraveling the mechanisms and exploring the antitoxic/antioxidant potentials of phytochemicals (natural and man-made antioxidants)
  • Investigation of the mechanism of environmentally exposed nanostructure-induced organ pathophysiology and its reversal by the nature derived active principles.

Research interest

As a team, we try to dissect each and every project into smaller fragments and treat every fragment as a complex puzzle. In order to unravel mechanisms underlying each puzzle, we follow a multi-pronged approach. Research activities mainly focus in understanding the mechanism of the initiation as well as regression of the organ (and/or individual) pathophysiology. Drug and environmental toxin-induced pathophysiological states and protective (preventive/curative) role of the naturally occurring bio-active molecules are of major interest. Specific assays include analysis of oxidative stress (production/ detoxification routes of reactive oxygen and nitrogen species as well as biological reactive intermediates), DNA damage and repair pathways, intracellular redox states and signal transduction mechanism. Prior to putting together the big-picture, we execute experiments at the organ level, cellular level, subcellular level (mitochondrial & nuclear), molecular level (microsomes) and at the genomic level (gene expression).

In addition, we are also investigating the mechanism of environmentally exposed nanostructure induced organ pathophysiology and its reversal by the nature derived active principle(s).

Finally, we try to compose each bit of the puzzle together. This strategy has consistently guided us in the right direction to understand how xenobiotics cause cellular toxicity and helped designing protocols to combat toxicity.

Guidance of PhD students: 8 [Eight]

Name of the Student University Year
Kasturi SarKar Calcutta 2006
Rajesh Bhattacharjee Jadavpur 2007
Ayantika Ghosh   Jadavpur 2008
Mrinal K Sarkar Jadavpur 2009
Prasenjit Manna Jadavpur 2010
Mahua Sinha Calcutta 2011
Jotirmoy Ghosh Jadavpur 2012
Joydeep Das   Jadavpur 2012

Ph.D. students [Research is in progress]: 9 [Nine]

Name of the Student Designation Joining Date
Pabitra Bikash Pal  SRF 2009 [CSIR Ad-hoc Fellow]
Sankhadeep Pal SRF  2010 [DAE Project Fellow]
Manoranjan Ghosh   SRF 2010 [CSIR Ad-hoc Fellow]
Semantee Bhattacharya SRF  2010 [CSIR Project Fellow]
Abhijit Sarkar  SRF  2010 [Bose Institute Fellow]
Sudip Bhattacharyya  JRF 2011 [CSIR Project Fellow]
 Krishnendu Sinha JRF 2011 [ICMR Ad-hoc Fellow]
Kahkashan Rashid  JRF [UGC-M. Azad National Fellow]
Satadal Ghosh JRF 2012 [UGC-Inspire Fellow]

Post-Docs:  1 (One)  

Name of the Student Designation Joining Date
Dr. Anandita Roy    Research Associate  CSIR 2010

Recent publications  

  1. Manna P, Das J, Sil PC (2013) Role of sulfur containing amino acids as an adjuvant therapy in the prevention of diabetes and its associated complications. Curr Diabetes Rev [Article in press].

  2. Sinha K, Das J, Pal PB, Sil PC (2013) Oxidative stress: the mitochondrial dependent and independent pathways of apoptosis. Arch Toxicol [Article in press; DOI: 10.1007/s00204-013-1034-4].

  3. Ghosh J, Sil PC (2013) Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine. Biochimie [Article in press; DOI: 10.1016/j.biochi.2013.01.016].

  4. Bhattacharya S, Gachhui R, Sil PC (2013) The prophylactic role of D-saccharic acid-1,4-lactone against hyperglycemia-induced hepatic apoptosis via inhibition of both extrinsic and intrinsic pathways in diabetic rats. Food Func 4:283-296.

  5. Bhattacharyya S, Pal PB, Sil PC (2013) A 35 kD Phyllanthus niruri protein modulates iron mediated oxidative impairment to hepatocytes via the inhibition of ERKs, p38 MAPKs and activation of PI3k/Akt pathway. Food Chem Toxicol 56:119-130.

  6. Pal PB, Sinha K, Sil PC (2013) Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-<kappa>B and mitochondria dependent pathways. PLoS ONE 8(2):e56894.

  7. Bhattachary S, Manna P, Gachhui R, Sil PC (2013) D-saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-<kappa>B and PKC signaling. Toxicol Appl Pharmacol 267(1):16-29.

  8. Rashid K, Das J, Sil PC (2013) Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food Chem Toxicol 51(1):317-329.

  9. Das J, Vasan V, Sil PC (2012) Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. Toxicol Appl Pharmacol 258 (2):296–308.

  10. Roy A, Sil PC (2012) Tertiary butyl hydroperoxide induced oxidative damage in mice erythrocytes: Protection by taurine. Pathophysiology 19(2):137-148.

  11. Pal S, Sil PC (2012) A 43 kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependent and independent pathways. Biochimie 94:1356-1367.

  12. Ghosh M, Das J, Sil PC (2012) D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-B and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a ployphenol xanthone, mangiferin. Free Radic Res 46(2):116–132.

  13. Das J, Vasan V, Sil PC (2012) Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. Toxicol Appl Pharmacol 258:296–308.

  14. Pal PB, Pal S, Manna P, Sil PC (2012) Traditional extract of Pithecellobium dulce fruits protects mice against CCl 4 induced renal oxidative impairments and necrotic cell death. Pathophysiology 19(2):101-114.

  15. Pal PB, Pal S, Das J, Sil PC (2012) Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes. Amino Acids 42:1669–1683.

  16. Roy A, Sil PC (2012) Taurine protects murine hepatocytes against oxidative stress-induced apoptosis by tert-butyl hydroperoxide via PI3K/Akt and mitochondrial-dependent pathways. Food Chem 131:1086-1096.

  17. Manna P, Sil PC (2012) Arjunolic acid: benefi cial role in type 1 diabetes and its associated organ pathophysiology. Free Radic Res 46(7):815-830.

  18. Das J, Ghosh J, Roy A, Sil PC (2012) Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFB pathways. Toxicol Appl Pharmacol 260:35–47.

  19. Manna P, Sil PC (2012) Impaired redox signaling and mitochondrial uncoupling contributes vascular inflammation and cardiac dysfunction in type 1 diabetes: Protective role of arjunolic acid. Biochimie 94:786-797.

  20. Das J, Ghosh J, Manna P, Sil PC (2012) Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis Amino Acids 42:1839–1855.

  21. Rashid K, Bhattacharya S, Sil PC (2012) Protective role of D-saccharic acid-1,4-lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway. Free Radic Res 46(3):240–252.

  22. Das J, Roy A, Sil PC (2012) Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review. Food Func 3(12):1251–1264.

  23. Ghosh J, Das J, Manna P, Sil PC (2011) The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53 mediated cardiac apoptosis. Biomaterials 32(21):4857-4866.

  24. Bhattacharya S, Manna P, Gachhui R, Sil PC (2011) Article title: D-saccharic acid-1,4-lactone ameliorates alloxan-induced Diabetes mellitus and oxidative stress in rats through inhibiting pancreatic beta-cells from apoptosis via mitochondrial dependent pathway. Toxicol Appl Pharmacol 257:272-283.

  25. Sarkar A, Manna P, Das J, Sil PC (2011) Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways. Toxicology 290:208-217.

  26. Sarkar K, Sil PC (2011) Cajanus indicus leaf protein:  Beneficial role in experimental organ pathophysiology. A review. Pathophysiology 18(4):295-303.

  27. Datta P, Mukhopadhyay AP, Manna P, Tiekink ER, Sil PC, Sinha C (2011) Structure, photophysics, electrochemistry, DFT calculation, and in-vitro antioxidant activity of coumarin Schiff base complexes of Group 6 metal carbonyls. J Inorg Biochem 105(4):577-588.

  28. Das J, Ghosh J, Manna P, Sil PC (2011) Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochem Pharmacol 81(7):891-909.

  29. Pal S, Pal PB, Das J, Sil PC (2011) Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro. Toxicology 283(2-3):129-139.

  30. Ghosh M, Manna P, Sil PC (2011) Protective role of a coumarin derived schiff base scaffold against TBHP induced oxidative impairment and cell death via MAPKs, NF-B and mitochondria dependent pathways. Free Radic Res 45(5): 620-637.

  31. Bhattacharya S, Gachhui R, Sil PC (2011) Hepatoprotective properties of Kombucha tea against TBHP-induced oxidative stress via suppression of mitochondria dependent apoptosis. Pathophysiology 18(3):221-234.

  32. Manna P, Bhattacharyya S, Das J, Ghosh J, Sil PC (2011) Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death. Evid-Based Compl Altern Med Article ID 832805, 17 pages, doi: 10.1155/2010/neq065.

  33. Bhattacharya S, Chatterjee S, Manna P, Das J, Ghosh J,  Gachhui R, Sil PC (2011) Prophylactic role of D-saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria dependent pathways. J Biochem Mol Toxicol 25:341-354.

  34. Bhattacharya S, Manna P, Gachhui R, Sil PC (2011) Protective effect of Kombucha tea against tertiary butyl hydroperoxide induced cytotoxicity and cell death in murine hepatocytes. Indian J Exp Biol 49(7):511-524.

  35. Ghosh J, Das J, Manna P, Sil PC (2010) Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-κB pathway activation. Free Radic Biol Med 49:1779-1791.

  36. Ghosh J, Das J, Manna P, Sil PC (2010) Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway. Food Chem 123:1062-1073.

  37. Das J, Ghosh J, Manna P, Sil PC (2010) Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKC-JNK Pathway. PLoS ONE 5:e12602.

  38. Sarkar MK, Sil PC (2010) Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri. Toxicol In Vitro 24:1711–1719. 

  39. Manna P, Das J, Ghosh J, Sil PC (2010) Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent Prophylactic role of arjunolic acid. Free Radic Biol Med 48:1465–1484.

  40. Manna P, Ghosh J, Das J, Sil PC (2010) Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid. Toxicol Appl Pharmacol 244:114-129.

  41. Ghosh J, Das J, Manna P, Sil PC (2010) Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection. Free Radic Biol Med 48:535-553.

  42. Das J, Ghosh J, Manna P, Sil PC. (2010) Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology 269(1):24-34.   

  43. Ghosh J, Das J, Manna P, Sil PC (2010) Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: Therapeutic potential of arjunolic acid. Toxicology 268:8-18.

  44. Das J, Ghosh J, Manna P, Sil PC (2010) Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res 44(3):340-355.

  45. Manna P, Sinha M, Sil PC (2009) Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades. Chem Biol Interact 181:297-308.

  46. Sinha M, Manna P, Sil PC (2009) Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine. J Trace Elem Med Biol 23(4):300-313.

  47. Roy A, Manna P, Sil PC (2009) Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/NF-kappaB and mitochondria dependent pathways. Free Radic Res 43:995-1007.                                  

  48. Ghosh J, Das J, Manna P, Sil PC (2009) Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-kappaB, p38 and JNK MAPK pathway. Toxicol Appl Pharmacol 240:73-87 [Cover page].

  49. Das J, Ghosh J, Manna P, Sinha M, Sil PC (2009) Arsenic-induced oxidative cerebral disorders: protection by taurine. Drug Chem Toxicol 32(2):93-102.

  50. Das J, Ghosh J, Manna P, Sinha M, Sil PC (2009) Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett 187:201-210.   

  51. Sarkar MK, Kinter M, Mazumder B, Sil PC (2009) Purification and characterization of a novel antioxidant protein molecule from Phyllanthus niruri. Food Chem 111:1405-1412.

  52. Manna P, Sinha M, Sil PC (2009) Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways. Toxicology 257 (1-2):53-63.

  53. Manna P, Sinha M and Sil PC (2009) Taurine plays a beneficial role against cadmium-induced oxidative renal dysfunction. Amino Acids 36(3):417-428.

  54. Ghosh A, Sil PC (2009) Protection of acetaminophen induced mitochondrial dysfunctions and hepatic necrosis via Akt-NF-B pathway: Role of a novel plant protein. Chem Biol Interact 177 (2):96-106.

  55. Ghosh J, Das J, Manna P, Sil PC (2008) Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. Toxicol In Vitro 22:1918-1926.

  56. Manna P, Sinha M, Sil PC (2008) Taurine triggers a chemoprevention against cadmium induced testicular oxidative injury. Reprod  Toxicol. 26:282-291.

  57. Sinha M, Manna P and Sil PC (2008) Terminalia arjuna protects mice hearts against sodium fluoride-induced oxidative stress. J Med Food 11:733-740.

  58. Sinha M, Manna P, Sil PC (2008) Taurine protects antioxidant defense system in the erythrocytes of cadmium treated mice. BMB Reports 41:657-663.

  59. Sinha M, Manna P, Sil PC (2008) Cadmium induced neurological disorders: Prophylactic role of taurine. J Appl Toxicol. 28:974-986.

  60. Das J, Ghosh J, Manna P, Sil PC (2008) Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes. Pathophysiology15:181-190.

  61. Manna P, Sinha M, Sil PC (2008) Amelioration of cadmium-induced cardiac impairment by taurine. Chem Biol Interact 174:88-97.

  62. Sinha M, Manna P, Sil PC (2008) Arjunolic acid attenuates arsenic-induced nephrotoxicity. Pathophysiology 15:147-156.

  63. Ghosh A, Sil PC (2008) A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress. Biol Pharm Bull 31:1651-1658.

  64. Manna P, Sinha M, Sil PC (2008) Arsenic induced oxidative myocardial injury: Protective role of arjunolic acid. Arch Toxicol. 82:137-149.

  65. Manna P, Sinha M, Sil PC (2008) Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Rep. 13:67-77.

  66. Sinha M, Manna P, Sil PC (2008) Protective Effect of Arjunolic Acid Against Arsenic-Induced Oxidative Stress in Mouse Brain. J Biochem Mol Toxicol 22:15-26.

  67. Manna P, Sinha M, Pal P, Sil PC (2007) Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes. Chem Biol Interact 170:187-200.

  68. Sinha M, Manna P, Sil PC (2007) Taurine, a conditionally essential amino acid, ameliorates arsenic-induced cytotoxicity in murine hepatocytes. Toxicol In Vitro 21:1419-1428.

  69. Sinha M, Manna P, Sil PC (2007) Attenuation of cadmium chloride induced cytotoxicity in murine hepatocytes by a protein isolated from the leaves of the herb Cajanus indicus L. Arch Toxicol. 81:397-406.

  70. Ghosh A, Sil PC (2007) Anti-oxidative effect of a protein from Cajanus indicus L against acetaminophen-induced hepato-nephro toxicity. J Biochem Mol Biol 40:1039-1049.

  71. Sarkar MK, Sil PC (2007) Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity. Pathophysiology 14:113-120.

  72. Sarkar K, Sil PC (2007) Attenuation of acetaminophen-induced hepatotoxicity in vivo and in vitro by a 43-kD protein isolated from the herb Cajanus indicus L. Toxicol Mech Methods 17:305-315.

  73. Bhattacharjee R, Sil PC (2007) Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem Toxicol 45:817-826.

  74. Manna P, Sinha M, Sil PC (2007) A 43 kD protein isolated from the herb Cajanus indicus L attenuates sodium fluoride-induced hepatic and renal disorders in vivo. J Biochem Mol Biol 40:382-395.

  75. Manna P, Sinha M, Sil PC (2007) Protection of arsenic-induced hepatic disorder by arjunolic Acid. Basic Clin Pharmacol Toxicol 101:333-338.

  76. Manna P, Sinha M, Sil PC (2007) Galactosamine-induced hepatotoxic effect and hepatoprotective role of a protein isolated from the herb Cajanus indicus L in vivo. J Biochem Mol Toxicol 21:13-23.

  77. Manna P, Sinha M, Sil PC (2007) Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress. Pathophysiology 14:71-78.

  78. Sinha M, Manna P, Sil PC (2007) Amelioration of galactosamine-induced nephrotoxicity by a protein isolated from the leaves of the herb, Cajanus indicus L. BMC Complement and Altern Med 7:11. 

  79. Sinha M, Manna P, Sil PC (2007) A 43 kD protein from the herb, Cajanus
    indicus L, plays protective role against sodium fluoride induced
    oxidative stress in mice erythrocytes. Pathophysiology 14:47-54.

  80. Chatterjee M, Sil PC (2007) Protective role of Phyllanthus niruri against nimesulide induced hepatic damage. Ind J Clin Biochem 22:109-116.

  81. Sinha M, Manna P, Sil PC (2007) Aqueous extract of the bark of Terminalia arjuna plays protective role against sodium fluoride induced hepatic and renal oxidative stress. J Nat Med 61:251-260.  

  82. Sarkar K, Ghosh A, Kinter M, Mazumder B, Sil PC (2006) Purification and characterization of a 43kD hepatoprotective protein from the herb Cajanus indicus L. Protein J 25:411-421.

  83. Sarkar K, Sil PC (2006) A 43kD protein from the herb Cajanus indicus L. protects thioacetamide induced cytotoxicity in hepatocytes. Toxicol In Vitro 20:634-640.

  84. Ghosh A, Sarkar K, Sil PC (2006) Protective effect of a 43kD protein from the leaves of the herb, Cajanus indicus L on chloroform induced hepatic-disorder. J Biochem Mol Biol 39:197-207.

  85. Chatterjee M, Sarkar K, Sil PC (2006) Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Pathophysiology 13:95-102.

  86. Bhattacharjee R, Sil PC (2006) Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity. Biomed Res 17:75-79.

  87. Manna P, Sinha M, Sil PC (2006) Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement and Altern Med  6:33.

  88. Chatterjee M, Sil PC (2006) Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian J Biochem Biophys  43:299-305.     

  89. Ghosh A, Sil PC (2006) A 43kD protein from the leaves of the herb, Cajanus indicus L, modulates chloroform induced hepatotoxicity in vitro. Drug Chem Toxicol 29:397-413.

  90. Bhattacharjee R, Sil PC (2006) The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytother Res. 20:595-601.

  91. Bhattacharjee R, Sil PC (2006) Protein isolate from the herb, Phyllanthus niruri, modulates carbon tetrachloride-induced cytotoxicity in hepatocytes. Toxicol Mech Methods. 17:41-47.

  92. Sarkar K, Ghosh A and Sil PC. (2005) Preventive and curative role of a 43kD protein from the leaves of the herb Cajanus indicus L on thioacetamide-induced hepatotoxicity in vivo. Hepatol Res 33:39-49.

  93. Sarkar M, Sarkar K, Bhattacharjee R, Chatterjee M and Sil PC.  (2005) Curative role of the aqueous extract of the herb, Phyllanthus niruri, against nimesulide induced oxidative stress in murine liver. Biomed Res 16:171-176.

  94. Sarkar K, Ghosh A and Sil PC. (2005) Preventive and curative role of a 43kD protein from the leaves of the herb Cajanus indicus L on thioacetamide-induced hepatotoxicity in vivo. Hepatol Res. 33: 39-49.

  95. Adhikary G, Gupta S, Sil P, Saad Y and Sen S. (2005) Characterization and functional significance of myotrophin: a gene with multiple transcripts. Gene 353:31-40.

  96. Sil P, Gupta S, Young D, and Sen S.  (2004) Effect of high pressure and pulsatile stretch on myotrophin gene expression. Mol Cell Biochem 262:79-89. 

  97. Sarkar S, Leaman DW, Gupta S, Sil P, Young D, Morehead A, Mukherjee D,Ratliff N, Sun Y, Rayborn M, Hollyfield J, Sen S. (2004) Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice. J Biol Chem 279:20422-20434.

  98. Mandal AK, Roy K, Yadav SP, Sil PC Sen PC (2001) Purification and characterization of a 70 kDa inhibitor    protein of Na+, K+-ATPase from goat testis cytosol. Mol Cell Biochem 223:7-14.

  99. Gupta S, Sil P, Young D, Sen S (1999) Initiation of cardiac hypertrophy by myotrophin: role of   NF-B. Circulation 100:2254. 

  100. Sil P, Kandoswamy V, Sen S (1999) Increased protein kinase C activity in myotrophin induced myocyte growth. Circ Res  82:1173-1188.

  101. Pathak M, Sil P, Young D, Sen S (1998) Ang II stimulated collagen production influenced by fibroblast myocyte cross talk. Circulation 98:3284.

  102. Sil P, Sen S (1997) Angiotensin II and myocyte growth: Role of fibroblasts. Hypertension 30:209-216.

  103. Sil P, Pathak M, Young D, Das J, Sen S (1997) Effect of myotrophin on initiation of cardiac hypertrophy. Circulation 96:1412.

  104. Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996) Cardiac Myotrophin Exhibits rel/NF-B Interacting Activity in vitro. J Biol Chem 271: 2812-2816.

  105. Sil P, Kandoswamy V, Sen S (1996) Cross-talk between myocytes and fibroblast in cardiac hypertrophy. J Mol Cell Cardiol 28: 173. 

  106. Sil P, Mukherjee D, Sen S (1995) Quantification of myotrophin from spontaneously hypertensive and normal rat hearts. Circ Res 76:1020-1027.

  107. Sil PC, Chaudhuri TK and Sinha NK. Basic Trypsin-Subtilisin Inhibitor from Marine Turtle Egg-white: Hydrodynamic and Inhibitory Properties. (1993) J Protein Chem 12:71-78.

  108. Sil P, Misono K, Sen S (1993) Myotrophin in Human cardiomyopathic Heart. Circ Res 73:98-108.

Citations, Impact factor h-index and i-index of the published papers:

            As seen in the list, more than 100 papers have been published in various well reputed international peer reviewed journals like Circulation Research, Hypertension, Biomaterials, Free Radical Biology & Medicine, Nanotoxicology, Journal of Biological Chemistry, PLoS ONE, Biochemical Pharmacology, Toxicology and Applied Pharmacology, Amino Acids, Toxicology Letters, Toxicology, Food Chemistry, etc. having high impact factors

 

Citations of the published papers is more than 2000, cumulative impact factor is approximately 325 with the h-index of 28 and i-10 index of 66.

 

Presented at Conferences / Seminars / symposia

i)          Delivered an invited talk entitled, “Beneficial Role of Herbal Plants in Pathophysiology” on 23.08.2008 in the Euro-India 1st International Conference on Holistic Medicine (ICHM-2008) in Kottayam, Kerala, India.

ii)       Delivered an invited talk in National Symposium on, “Acharyya Prafulla Chandra Ray and Chemistry Today” at the University College of Science, University of Calcutta, entitled “Role of Macromolecules in Pathophysiology”, 2007.

iii)       Delivered an invited Inaugural talk in the Science Fair in MTPS, DVC, Bankura, WB; 2004.

iv)      Delivered an invited talk in the Refresher Course in Chemistry, University College of Science, University of Calcutta, entitled “Genes and Proteins in Human Pathophysiology”, 2003.

v)            Presented in National Symposium on “Plant physiology and biochemistry in transgenic era and beyond”, Bose Institute, 2002.

vi)           Presented in the Scientific Sessions of the American Heart Association Annual Meeting in Dallas, TX, USA (1999).

vii)          Presented in the Scientific Sessions of the American Heart Association Annual Meeting in New Orleans, LA 70130, USA (1998).

viii)         Presented in the Scientific Sessions of the American Heart Association Annual Meeting in Orlando, FL, USA (1997).

ix)           Presented in The International Society of Heart Research North American Section Meeting in Chicago, IL, USA (1996).

x)            Presented in the Scientific Sessions of the American Heart Association Annual Meeting in Anaheim, CA, USA (1995).

xi)           Presented in the Scientific Sessions of the American Heart Association Annual Meeting in Dallas, TX, USA (1994).

xii)          Presented in the Scientific Sessions of the American Heart Association Annual Meeting in Atlanta, GA, USA (1993).

xiii)         Presented in the Scientific Sessions of the American Heart Association Annual Meeting in New Orleans, LA, USA (1992).

xiv)            Presented in The Federation of American Societies for Experimental Biology (FASEB) Conference in Atlanta, GA, USA (1991).

Membership of Learned Societies 

The Indian Science Congress Association (Life Member)

Indian Society of Cell Biology (Life Member)

Indian Society of Biological Sciences (Life Member) 

Reviewer  

  1. Acta Pharmacologica Sinica

  2. Acta Biochimica et Biophysica Sinica

  3. Adaptive Medicine

  4. Amino Acids

  5. Animals

  6. Antioxidant & Redox Signaling

  7. Asian J Andrology

  8. Archives of Pharmacal Research

  9. Basic & Clinical Pharmacology & Toxicology

  10. Biochemical Pharmacology

  11. Biochemistry Research International

  12. Biological Trace Element Research

  13. Biomedical Research

  14. BMC-Cancer

  15. BMC-Clinical Pharmacology

  16. BMC-Complementary and Alternative Medicine

  17. BMC-Journal of Occupational Medicine and Toxicology

  18. British Biotechnology Journal

  19. British Journal of Medicine and Medical Research

  20. British Journal of Pharmaceutical Research

  21. Cell Biology and Toxicology

  22. Chemico-Biological Interactions

  23. Chemosphere

  24. Clinical Reviews and Opinions

  25. Current Diabetes Reviews

  26. Current Drug Safety

  27. Current Medicinal Chemistry

  28. Current Pharmaceutical Analysis

  29. Ecotoxicology and Environmental Safety

  30. Endocrine Research

  31. Environmental Toxicology

  32. Environmental Toxicology and Pharmacology

  33. Expert Opinion On Drug Discovery

  34. Experimental Biology and Medicine

  35. European Journal of Nutrition

  36. European Journal of Pharmacology

  37. Evidence Based Complementary and Alternative Medicine

  39. Food chemistry

  40. Free Radical Biology & Medicine

  41. Fresenius Environmental Bulletin

  42. General Physiology and Biophysics

  43. Indian Journal of Biochemistry and Biophysics

  44. Indian Journal Clinical Biochemistry

  45. Indian Journal Experimental Biology

  46. Indian Journal of Medical Research

  47. Indian Journal of Natural Product Research

  48. International Journal of Cardiology

  49. International Journal of Cell Biology

  50. International Journal of Medicine and Medical Sciences (IJMMS)

  51. International Journal of Green Pharmacy

  53. International Research Journals of Biochemistry and Bioinformatics(IRJBB)

  54. International Research Journal of Plant Science

  55. Iranian Journal of Pharmacology & Therapeutics

  56. Journal of Agricultural and Food Chemistry

  57. Journal of Biomedical Materials Research: Part A

  58. Journal of Biomedical Nanotechnology

  59. Journal of Basic and Clinical Physiology and Pharmacology

  60. Journal of Diabetes and Its Complications

  61. Journal of Chinese Integrative Medicine

  62. Journal of Clinical Trials

  63. Journal of Diabetes and Endocrinology

  64. Journal of Food Biochemistry

  65. Journal of  Functional Food

  66. Journal of Hazardous Materials

  67. Journal of Herbs, Spices and Medicinal Plants

  68. Journal of Medicine and Medical Sciences

  69. Journal of Medicinal Food

  70. Journal of Medicinal Plants Research

  71. Journal of Neuroscience and Behavioural Health

  72. Journal of Occupational Medicine and Toxicology

  73. Journal of Pharmacy & Pharmacology

  74. Journal of Physiology and Pathophysiology

  75. Journal of Plant Breeding and Crop Science (JPBCS)

  76. Journal of Surface Science and Technology

  77. Journal of Trace Elements in Medicine and Biology

  78. Kidney International

  79. Life Sciences and Medicine Research

  80. Lipids

  81. Medical Practice and Reviews

  82. Mini-Reviews in Medicinal Chemistry

  83. Molecular Cancer Research

  84. Molecules

  85. Mutation Research

  86. Natural Product Research

  87. Nephrology

  88. Neurochemistry International

  89. Neurotoxicity Research

  90. Open Veterinary Journal

  91. Oriental Pharmacy and Experimental Medicine

  92. Pediatric Research

  93. Pesticide Biochemistry and Physiology

  94. PLoS ONE

  95. Process Biochemistry

  96. Recent Patents on Cardiovascular Drug Discovery

  97. Redox Report

  98. Reproductive Biology

  99. Science & Culture

  100. Scientia Pharmaceutica

  101. Theriogenology

  102. The International Journal of Biochemistry & Cell Biology

  103. Theoretical Biology and Medical Modelling

  104. Toxicology and Applied Pharmacology

  105. Toxicology and Industrial Health

  106. Toxicology

  107. Toxicology In Vitro [Top Reviewer, 2009 & 2010]

  108. Toxicology Research 

  109. Toxicology Mechanisms and Methods

Examinership 

PhD Thesis examiner: [Calcutta University, Jadavpur University, Pune University, Visva-Bharati university, Gauhati University, Bhartihar University, Annamalai University, Jamia Hamdard University, Madras University, etc. ]

External examiner: M.Sc. (Chemistry) examination [Calcutta University]

Examiner: JBNSTS  

Teaching Experience 

Pre-doctoral Course Work:

Course: Protein to Proteomics [Bose Institute]

Integrated MSc-PhD: Plant Molecular Biology and Biotechnology

Course: Basic physical chemistry and Bioenergetics

 Toxicology and Pathophysiology [In collaboration with CU]

 

Contact Information
Phone: 9133-25693243
FAX: 9133-2355-3886
E-mail: parames@bosemain.boseinst.ac.in;parames_95@yahoo.co.in