Professor and Head
Division of Molecular Medicine
(Formerly Professor of Chemistry)
University of Calcutta (1977)
The main research
interest is to work on different biochemical aspects of various transport
enzymes e.g. Na+ ,K +-ATPase, Ca2+,Mg
2+-ATPase, Ca2+-ATPase etc. and their interactions with
different drugs (contraceptive and amphiphilic) and lipids in natural and
model membranes; fluorescence behaviour of enzymes and how their
function/activity are affected under various experimental (e.g. drug
induced) conditions ; mechanism of regulation of transport enzymes by
protein kinase (through phosphorylation), endogenous stimulator and/or
inhibitor proteins( to explore their role not only in cell regulation but to
study them in detail in order to examine if they have any phamacological
importance and to use these modulators as drugs particularly as
contraceptive drugs ), determination of amino acid sequence of the regulator
proteins, synthesise peptides corresponding to the sequence, examine the
effect of the synthetic peptides and compare with the parent protein.
Regulation of ATPases by synthetic compounds analog to certain know
stimulators/inhibitors of the ATPases and study their possible use as
Recently we have
oriented our work to some synthetic compounds which are found to regulate
different ion transporting enzymes. A group of compound analog of calcium
blockers has been synthesized and their effects on Ca2+-ATPase
are being investigated. One of these compounds is found to be quite
effective not only as an inhibitor of SERCA but also induces apoptosis in
breast cancer cells to a significant level.
Name of other group members
List of Publications (in last five years)
Bhattacharyya, A. Basu and P.C.Sen. Purification of protein from a
crude mixture through SDS-PAGE transfer method. Ind.J.Biochem.Biophys. 44,
Kundu, P.C.Sen and K. P. Das. Structure, Stability and Chaperone
Function of α-crystallin Crystallin: Role of the N-Terminal Region.
Biopolymers 86: 177-192, 2007
Samanta, S.K. Nagdas, K.P. Das and P.C. Sen Protein kinase catalytic
PKAcat) from bovine lens: Purification, characterization and phosphorylation
of lens crystallins. Mol.Cell.Biochem. 304, 155-165, 2007
Sengupta, SS. Ghosha, S. Dunggung, G.C. Majumder and P.C.Sen .
Structural and functional characterization and physiological significance of
a stimulation protein of Mg2+-independent Ca2+-ATPase
isolated rom goat spermatozoa. Mol.Cell.Biochem. 311, 93-103, 2008.
Ghoshal, T. Sengupta, G. C. Majumder and P. C. Sen Characterization
of a low molecular mass stimulator protein of Mg2+-independent Ca2+-ATPase
: effect on phosphorylation-dephosphorylation, calcium transport and sperm
cell motility. Biosc. Report . 28, 61-71, 2008.
T.K.Ray, P. Das, P.C.Sen and J. Nandi. Current Outlooks on the
Gastric Membranes and Beyond. Trends in Cell and Molecular Biology (
Review). 3, 69-78, 2008
M.Chatterjee, P.Das, A.Mazumder, A.K.Nagdas and P.C.Sen.
Localization and expression of a 70 kDa protein in goat spermatozoa having
Na,,K-ATPase and aryl sulphatase –A activities. Mol.Cell.Biochem. 321,
K. Dhara, M. Chatterjee, R. Bera and P. C. Sen. Characterization of
arylsulphatase A in a 70 kDa protein isolated from goat spermatozoa having
inhibitory activity. Ind.J.Biochem. Biophys. 46, 230-236, 2009
9. M. Chatterjee, P. Nandi, S. Ghosh and P. C. Sen.
Regulation of tyrosine kinase activity during capacitation in goat sperm.
Mol.Cell.Biochem. ((Special Issue on Molecular Medicine and Cell
Signaling)) 336, 39-48, 2010
10. R. Bera, T. K. Dhara, R. Bhadra, G. C. Majumder and P. C Sen.
Eicosapentaenoic and docosahexaenoic acids enriched polyunsaturated fatty
acids from the coastal marine fish of Bay of Bengal and their therapeutic
value. Ind.J.Expt.Biol. 48, 1194-1203, 2010
Mukherjee, S. Ghosh, P. Nandi, P. C. Sen and A. K. Misra, Efficient
synthesis of (6,6¢)-sulfonyl pseudodisaccharides and their effect on
Ca2+-ATPase. Eur. J. Med. Chem. 45, 6012-6019, 2010
P. C. Sen. Endogenous modulators in the regulation of ion transporting
enzymes : A historical account, recent developments and future perspectives.
Adv. Biol. Chem. (Review) 1, 75-92, 2011
13. K. Jana and P. C. Sen. Environmental Toxicants Induced Male
Reproductive Disorders: Identification and Mechanism of Action. In ‘Toxicity
and Drug Testing”. in Toxicity and Drug Testing, Edited by William Acree,
Intech Publication, Croatia, pp. 473-518, 2012.
Nandi, S. Ghosh, K. Jana and P. C. Sen. . Elucidation of the
Involvement of p14, a Sperm Protein During Maturation, Capacitation and
Acrosome Reaction of Caprine Spermatozoa. PLoS One, 7(1), 230552, 2012.
K. Dhara, R. Bera, R. Bhadra and P. C. Sen. Aryl sulphatase
and ultrastructural changes in different organs of rat during streptozotocin
induced diabetes and the effect of polyunsaturated fatty acids. J.
Pharmaceut. Biomed. Sc. 16 (3), 1-8, 2012
Putatunda, S. Chakraborty, S. Ghosh, P. Nandi, S. Chakraborty, P. C Sen,
A. Chakrabort. Regioselective N1-Alkylation of 3,
4-dihydropyrimidine-2(1H)-ones: Screening of their biological activities
against Ca2+-ATPase. Eur. J. Med. Chem. (Press, 2012)
P.C. Sen. Endogenous modulators in the regulation of ion transporting
enzymes. Ind. J. Physiol. (Press, 2012)
18. P.C. Sen.
study of marine derived fatty acids and their therapeutic importance.
In “Marine Biomaterials: Isolation, characterization and Applications”.
Edited by Se-Kwon Kim, CRC/Taylor
and Francis (Press, 2012)
S. Ghosh, A. Adhikary, S. Chakraborty, P. Nandi, S. Mohanty,
S. Chakraborty, P. Bhattacharjee, S.
S. utatunda, S. Chakraborty, A. Chakraborty, G. Sa, T. Das and P.C.Sen.
Nifetepimine, a dihydropyrimidone ensures CD4+
T cell survival in tumor micro-environment by maneuvering SERCA
[Details of Publications]
National Academy of Sciences ( F.N.A.Sc.), India
2. Fellow of the West Bengal Academy of Science and
Sen Oration Award from the Physiological Society of India, 2010
2. Prof. P.A.Kurup Endowment Award from the Society of Biological
Chemists (India), 2000
3. Prof. R.C. Shah Memorial Award from Indian Science Congress
Association, 1997 - 98
4. DPI Scholarship, Govt. of West Bengal, 1971 -1973
Guest Editor of Special Issue on
SIGNALING & MOLECULAR MEDICINE
published by Springer in
Molecular and Cellular Biochemistry
Reference India, Vol. 3, 1995
WHO’s Who in the world 1997