Tel: 91-33-2569-3222
Fax:  91-33-2355-3886

E-mail: parimalsen.boseinst@gmail.com
           parimal@bic.boseinst.ernet.in

Research interest

The main research interest is to work on different biochemical aspects of  various  transport  enzymes e.g. Na⁺ ,K ⁺-ATPase, Ca²⁺,Mg ²⁺-ATPase, Ca²⁺-ATPase etc. and their interactions with different drugs (contraceptive and amphiphilic) and lipids in natural and model membranes; fluorescence behaviour of enzymes and how their function/activity are affected under various experimental (e.g. drug induced) conditions ; mechanism of regulation of transport enzymes by protein kinase (through phosphorylation),  endogenous stimulator and/or inhibitor proteins( to explore their role not only in cell regulation but to study them in detail in order to examine if they have any phamacological importance and to use these modulators as drugs particularly as contraceptive drugs ), determination of amino acid sequence of the regulator proteins, synthesise peptides corresponding to the sequence, examine the effect of the synthetic peptides and compare with the parent protein.  Regulation of ATPases by synthetic compounds analog to certain know stimulators/inhibitors of the ATPases and study their possible use as anticancer agent.
Recently we have oriented our work to some synthetic compounds which are found to regulate different ion transporting enzymes. A  group of compound analog of calcium blockers has been synthesized and their effects on Ca²⁺-ATPase are being investigated. One of these compounds is found to be quite effective not only as an inhibitor of SERCA but also induces apoptosis in breast cancer cells to a significant level.    

Name of other group members

• Dr. Nivedita Roy
• Dr. AparajitaGhosh
• Pinki Nandy
• Sawtilekha Ghosh
• Supriya Chakrabarty
• Arindam Basu
• Kalyn Das

List of Publications (in last five years) 

1. D. Bhattacharyya, A. Basu and P.C.Sen. Purification of protein from a crude mixture through SDS-PAGE transfer method.  Ind.J.Biochem.Biophys. 44, 122-125, 2007 

2. M. Kundu, P.C.Sen  and K. P. Das. Structure, Stability and Chaperone Function of  α-crystallin Crystallin:  Role of the N-Terminal Region. Biopolymers 86: 177-192, 2007

3. B. Samanta, S.K. Nagdas, K.P. Das and P.C. Sen Protein kinase catalytic subunit

( PKAcat) from bovine lens: Purification, characterization and phosphorylation of lens crystallins. Mol.Cell.Biochem. 304, 155-165, 2007 

4.  T.  Sengupta,  SS. Ghosha, S.  Dunggung, G.C. Majumder and P.C.Sen .  Structural and functional characterization and physiological significance of a stimulation protein of  Mg²⁺-independent Ca²⁺-ATPase isolated rom goat spermatozoa. Mol.Cell.Biochem. 311, 93-103, 2008.

5.  S. Ghoshal, T. Sengupta, G. C. Majumder and P. C. Sen Characterization of a low molecular mass stimulator protein of Mg²⁺-independent Ca²⁺-ATPase : effect on phosphorylation-dephosphorylation, calcium transport and sperm cell motility.  Biosc. Report . 28, 61-71, 2008.

6.  T.K.Ray, P. Das, P.C.Sen and J. Nandi. Current Outlooks on the Gastric Membranes and Beyond. Trends in Cell and Molecular Biology ( Review). 3, 69-78, 2008

7. M.Chatterjee, P.Das, A.Mazumder, A.K.Nagdas and P.C.Sen.  Localization  and expression of  a 70 kDa protein in goat spermatozoa having Na,,K-ATPase and  aryl sulphatase –A activities. Mol.Cell.Biochem. 321, 85-94, 2009 

8. T. K. Dhara, M. Chatterjee, R. Bera and P. C. Sen. Characterization of arylsulphatase A in a 70 kDa protein isolated from goat spermatozoa having Na⁺, K⁺-ATPase inhibitory activity. Ind.J.Biochem. Biophys.  46, 230-236, 2009

9. M. Chatterjee, P. Nandi, S.  Ghosh and P. C. Sen. Regulation of tyrosine kinase activity during capacitation in goat sperm. Mol.Cell.Biochem. ((Special Issue on Molecular Medicine and Cell Signaling)) 336, 39-48, 2010

10.  R. Bera, T. K. Dhara, R. Bhadra, G. C. Majumder and P. C Sen^.  Eicosapentaenoic and docosahexaenoic acids enriched polyunsaturated fatty acids from the coastal marine fish of Bay of Bengal and their therapeutic value. Ind.J.Expt.Biol. 48, 1194-1203, 2010

11. C. Mukherjee, S. Ghosh, P. Nandi, P. C. Sen and A. K. Misra, Efficient synthesis of (6,6¢)-sulfonyl pseudodisaccharides and their effect on Ca2+-ATPase. Eur. J. Med. Chem. 45, 6012-6019, 2010

12. P.  C. Sen. Endogenous modulators in the regulation of ion transporting enzymes : A historical account, recent developments and future perspectives. Adv. Biol. Chem. (Review) 1, 75-92, 2011

13. K. Jana and P. C. Sen. Environmental Toxicants Induced Male Reproductive Disorders: Identification and Mechanism of Action. In ‘Toxicity and Drug Testing”. in Toxicity and Drug Testing, Edited by William Acree, Intech Publication, Croatia, pp. 473-518, 2012.

14. P. Nandi, S. Ghosh, K. Jana and P. C. Sen. . Elucidation of the Involvement of p14, a Sperm Protein During Maturation, Capacitation and Acrosome Reaction of Caprine Spermatozoa. PLoS One, 7(1),  230552,  2012. doi:10.137!jornal.pone::00552.

15. T. K. Dhara, R. Bera, R. Bhadra and P. C. Sen. Aryl sulphatase and ultrastructural changes in different organs of rat during streptozotocin induced diabetes and the effect of polyunsaturated fatty acids. J.  Pharmaceut. Biomed. Sc. 16 (3), 1-8, 2012 

16.  S. Putatunda, S. Chakraborty, S. Ghosh, P. Nandi, S. Chakraborty, P. C Sen, A. Chakrabort. Regioselective N1-Alkylation of 3, 4-dihydropyrimidine-2(1H)-ones: Screening of their biological activities against Ca²⁺-ATPase. Eur. J. Med. Chem. (Press, 2012) 

17. P.C. Sen. Endogenous modulators in the regulation of ion transporting enzymes. Ind. J. Physiol. (Press, 2012)

18. P.C. Sen. A study of marine derived fatty acids and their therapeutic importance. In “Marine Biomaterials: Isolation, characterization and Applications”. Edited by Se-Kwon Kim, CRC/Taylor and Francis (Press, 2012)

 19. S. Ghosh, A. Adhikary, S. Chakraborty, P. Nandi, S. Mohanty, S. Chakraborty, P. Bhattacharjee, S. Mukherjee, S. utatunda, S. Chakraborty, A. Chakraborty, G. Sa, T. Das and P.C.Sen. Nifetepimine, a dihydropyrimidone ensures CD4⁺ T cell survival in tumor micro-environment by maneuvering SERCA (Communicated)

[Details of Publications]

Fellow

 1.   The National Academy of Sciences ( F.N.A.Sc.), India

 2.   Fellow of the West Bengal Academy of Science and Technology (F.A.Sc.T.)

Awards              

1.      Prof. P.B. Sen Oration Award from the   Physiological Society of India, 2010               

     2.    Prof. P.A.Kurup Endowment Award from the Society of Biological Chemists (India), 2000

     3.   Prof. R.C. Shah Memorial Award from Indian Science Congress Association, 1997 - 98

     4.   DPI Scholarship, Govt. of West Bengal, 1971 -1973

Recognition

• Guest Editor of Special Issue on CELL SIGNALING & MOLECULAR MEDICINE published by Springer in
• Molecular and Cellular Biochemistry 
• Reference India, Vol. 3, 1995
• WHO’s Who in the world 1997