Tanya Das, Ph.D.

List of publications in reverse chronological order

 Peer reviewed journals 

1.     Chakrabarty J, Banerjee S, Roy P, Bhattacharyya S, Hossain D Md. S, Adhikary A, Chattopadhyay S, Das T and Sa G. Gain of cellular adaptation due to prolong p53 impairment leads to functional switch-over from p53 to p73 during DNA damage in acute myeloid leukemia cells. J. Biol. Chem. (In press) (2010)

2.     Lahiry L, Saha B, Chakraborty J, Adhikary A, Banerjee S, Das K, Sa G and Das T. Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. Carcinogenesis  31, 259-68 (2010)

3.     Adhikary A, Mohanty S, Lahiry L, Hossain D Md. S, Chakraborty S and Das T Theaflavins retard human breast cancer cell migration by inhibiting NF-kB via p53-dependent ROS generation. FEBS Letts. 584, 7-14 (2010)

4.     Bhattacharyya S, Hossain D Md. S, Mohanty S, Sen GS, Chattopadhyay S, Banerjee S, Chakraborty J, Das K, Sarkar D, Das T and  Sa G. Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor‐bearing host. Cell. Mol. Immunol. 7, 306-15 (2010)

5.     Chattopadhyay S, Bhattacharyya S, Saha B, Chakrabarty J, Mohanty S, Hossain DMS, Banerjee S, Das K, Sa G and Das T. Tumor-shed PGE2 impairs IL2Rgc-signaling to inhibit CD4+ T cell survival: Regulation by theaflavins. PLoS One 4, e7382 (2009)

6.     Chatterjee S, Mookerjee A, Mookerjee Basu J, Chakraborty P, Ganguly A,
Adhikary A, Mukhopadhyay D, Banerjee R, Ashraf M, Biswas J, Das PK, Sa G, Chatterjee M, Das T and Chaudhuri SK. CuNG, a novel copper complex, modulates drug resistant tumor associated macrohages to reprogram T cells to elicit anti-tumor response. PLoS One 4, e7048 (2009)

7.     Sa G, Das T, Moon C, Hilston CM, Rayman PA, Rini BI, Tannenbaum CS, Finke JH. GD3, an Overexpressed Tumor-Derived Ganglioside, Mediates the Apoptosis of Activated but not Resting T Cells. Cancer Res. 69, 3095-104, 2009 [Sa G and Das T both contributed equally to this paper].

8.     Lahiry L, Saha B, Chakraborty J, Bhattacharyya S, Chattopadhyay S, Choudhuri T, Mandal D, Bhattacharyya A, Sa G and Das T. Contribution of p53-mediated transcription-dependent pathway in mammary epithelial carcinoma cell apoptosis by theaflavins. Apoptosis 13, 771-81 (2008)

9.     Das T, Sa G, Paszkiewicz-Kozik E, Hilston C, Molto L, Rayman P, Biswas K, Kudo D, Bukowski RM, Finke JH and Tannenbaum C. Tumors Induce T Cell Apoptosis Through Receptor-Dependent and Receptor-Independent Pathways. J. Immunol. 180, 4687-96 (2008)

10.            Das T, Sa G, Hilston C, Kudo D, Rayman P, Biswas K, Molto L, Bukowski R, Rini B, Finke JH and Tannenbaum C. GM1 and TNFa, overexpressed in renal cell carcinoma, synergize to induce T cell apoptosis. Cancer Research 68, 2014-23 (2008)

11.      Sa G, Das T. Anti cancer effects of curcumin: cycle of life and death. Cell Div. 3, 14 (2008)

12.      Bhattacharyya A, Mandal D, Lahiry L, Bhattacharyya S, Chattopadhyay S, Ghosh UK, Sa G and Das T. Black Tea-Induced Amelioration of Hepatic Oxidative Stress through Antioxidative Activity in EAC-Bearing Mice. J Environ Pathol Toxicol Oncol. 26, 245-54 (2007)

13.      Bhattacharyya S, Mandal D, Saha B, Sen GS, Das T and Sa G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem. 282, 15954-64 (2007)

14.      Mandal D, Bhattacharyya S, Lahiry L, Chattopadhyay S, Sa G and Das T. Black tea-induced decrease in IL-10 and TGF-b of tumor cells promotes Th1/Tc1 response in tumor-bearer. Nutrition Cancer 58, 213-21 (2007)

15.      Raval G, Biswas S, Rayman P, Biswas K, Sa G, Ghosh S, Thornton M, Hilston C, Das T, Bukowski R, Finke J and Tannenbaum CS.  TNF-α Induction of GM2 Expression on Renal Cell Carcinomas Promotes T cell Dysfunction. J Immunol. 178, 6642-522 (2007)

16.      Bhattacharyya S, Mandal D, Sen GS, Pal S, Banerjee S, Lahiry L, Finke JH, Tannenbum CS, Das T and Sa G. Tumor-induced oxidative stress perturbs NFkB activity augmenting TNFa-mediated T cell death: Protection by curcumin. Cancer Research. 67, 362-70 (2007)

17.      Chattopadhyay S, Saha B, Mandal D, Sa G & Das T. Black tea: A Review. In: Economic Crisis in Tea Industry: Strategies for Scientific Management.  (Ed: Dr. F. Rahman and Dr. Peter Baker). ISTS Book 3 of the Book series Global Advances in Tea Science. Studium Press LLC, Houston Texas, USA. Chapter 34, (2007)

18.      Dasgupta R, Saha I, Pal S, Bhattacharyya A, Sa G, Nag TC, Das T and Maiti BR. Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline. Toxicology 227:94-104, 2006 [Das T & Maity BR both are corresponding authors in this paper]

19.      Das T, Sa G and Siddiqi M. Potential targets of tea polyphenols in cancer prevention: significance in angiogenesis, metastasis and apoptosis as well as in protection of host defense system. In: Protective effects of tea on human health (Eds. J Weisberger, N K Jain and M Siddiqi) Cabi London, 76-90, 2006.

20.      Biswas K, Richmond A , Rayman P, Biswas S, Thornton M, Sa G, Das T, Zhang R, Chahlavi A, Tannenbaum CS, Novick A, Bukowski R and Finke JH. GM2 Expression in renal cell carcinoma: Potential role in tumor-induced immune dysfunction. Cancer Research. 66:6816-25, 2006.

21.      Mookerjee A, Mookerjee Basu J, Dutta P, Majumder S, Bhattacharyya S, Biswas J, Pal S, Mukherjee P, Raha S, Baral RN, Das T, Efferth T, Sa G, Roy S, Choudhuri SK. Overcoming drug resistant cancer by a newly developed copper chelate through host protective cytokine mediated apoptosis. Clinical Cancer Research 12:4339-49, 2006 .

22.      Bhattacharyya A, Lahiry L, Mandal D, Sa G and Das T. Black tea induces tumor cell apoptosis by Bax translocation, loss in mitochondrial transmembrane potential, cytochrome c release and caspase activation. Int. J. Cancer 117:308-15, 2005.

23.      Mandal D, Bhattacharyya A, Lahiry L, Bhattacharyya S, Sa G and Das T. Tumor-induced thymic involution via Inhibition of IL-7Ra and its JAK-STAT signaling pathway: Protection by Black Tea. Int. Immunopharmacol. 6:433-44, 2005.

24.      Pal S, Bhattacharya S, Choudhuri T, Datta GK, Das T and Sa G. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detection Prevention, 29:470-8, 2005.

25.      Mandal D, Bhattacharyya A, Lahiry L, Sa G and Das T. Failure in peripheral immuno-surveillance due to thymic atrophy: Importance of thymocyte maturation and apoptosis in adult tumor-bearer. Life Sci. 77:2703-16, 2005.

26.      Choudhuri T, Pal S, Das T & Sa G. Curcumin selectively induces apoptosis in deregu­lated cyclin D1 expressed cells at G2 phase of cell cycle in a p53-dependent manner. J. Biol. Chem. 280:20059-68, 2005 .

27.      Mandal D, Lahiry L, Bhattacharyya A, Chattopadhyay S, Siddiqi M, Sa G and Das T. Black tea protects thymocytes in tumor-bearers by differential regulation of intracellular ROS in tumor cells and thymocytes. J. Environ. Toxicol. Pathol. Oncol. 24:91-104, 2005.

28.      Bandyopadhyay S, Bhattacharyya A, Mallick A, Sen AK, Tripathi G, Das T, Sa G, Bhattacharya DK and Mandal C. Over expressed IgG2 antibodies against O-acetylated sialoglycoconjugates incapable of proper effector functioning in childhood acute lymphoblastic leukemia. Int. Immunol. 17:177-91, 2005.

29.      Bhattacharyya A, Mandal D, Lahiry L, Sa G & Das T. Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio. Cancer Lett 209: 147-154, 2004.

30.      Rayman P, Wesa AK, Richmond AL, Das T, Biswas K, Storkus WJ, Tannenbaum C, Novick A, Bukowksi R & Finke J. Effect of Renal Cell Carcinomas on the Development of Type I T Cell Responses. Clinical Cancer Research 10: 6360-6366, 2004.

31.      Mandal D, Lahiry L, Bhattacharyya A, Bhattacharyya A, Sa G & Das T.  Pharmacotherapeutics of tea: Proposed strategies and pharmacological studies. Int J Tea Sci 3: 261-272, 2004.

32.      Finke JH, Tannenbaum C, Storkus W, Rayman P, Das T, Biswas K, Richmond A, Moon C, Thornton M, Gill I, Novick A & Bukowski R. Tumor-induced dysfunction in T lymphocytes: increased sensitivity to apoptosis. Urologe A 43:131-132, 2004.

33.      Bhattacharyya A, Chattopadhyay S, Choudhury T, Banerjee A, Sa G & Das T. Apoptogenic effects of black tea on Ehrlich's ascites carcinoma cell. Carcinogenesis 24: 75-80, 2003.

34.      Molto L, Rayman P, Paszkiewicz-Kozik E, Thornton M, Reese L, Thomas JC, Das T, Kudo D, Bukowski R, Finke J & Tannenbaum C. The Bcl-2 transgene protects T cells from renal cell carcinoma-mediated apoptosis. Clin Cancer Res. 9: 4060-4068, 2003.

35.      Bhattacharyya A, Sa G, Das T & Siddiqi M. Black tea-induced cellular survival: Evidence for reduced toxicity and enhanced immunity in mice under stress. Int J Tea Sci 2: 34-39, 2003,

36.      Choudhuri T, Pal S, Agwarwal ML, Das T and Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 512, 334-340, 2002.

37.      Das T, Sa G, Chattopadhyay S and Ray PK. Protein A-induced apoptosis of cancer cells is affected by soluble immune mediators. Cancer Immunol. Immuno­therapy 51, 376-380, 2002.

38.      Chattopadhyay S, Das T, Sa G, and Ray PK. Protein A-activated macrophages induce apoptosis in Ehrlich's ascites carcinoma through a nitric oxide-dependent pathway. Apoptosis 7, 49-57, 2002.

39.      Ghosh S, Bhattacharyya S, Sirkar M, Sa G, Das T, Majumdar D, Roy S and Majumdar S. (2002) Leishmania donovani suppresses activated protein 1 and NF-kappaB activation in host macrophages via ceramide generation: Involvement of extra­cellular signal-regu­lated kinase. Infect Immun 70, 6828-6838.

40.      Pal S, Choudhuri T, Chattopadhyay S, Bhattacharya A, Datta GK, Das T & Sa G. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem Biophys Res Commun 288: 658-665, 2001.

41.      Ray PK, Das T, Sa G, Ghosh AK & Chattopadhyay S. Protec­tion of apoptotic cell death by Protein A. Apoptosis 5: 509-514, 2000.

42.      Das T, Sa G, Subbulakshmi V, Subramaniam S, Sen PC, Biswas S & Ray PK. Protein A-acti­vated rat spleenic lymphocyte proliferation involves tyrosine kinase - phospholipase C - protein kinase C pathway. Immunopharmacol. Immunotoxicol. 22: 75-90, 2000.

43.      Ghosh AK, Jana S, Das T, Sa G, Mondal N & Ray PK. Protection by Protein A of apoptotic death caused by anti-AIDS drug zidovudine. Biochem. Biophys. Res. Commun. 264: 601-604, 1999.

44.      Das T, Sa G & Ray PK. Mechanisms of Protein A superantigen-induced signal transduction for proliferation of mouse B cells. Immunol. Lett. 70: 43-51, 1999.

45.      Das T, Sa G, Sinha P, & Ray PK. Induction of cell proliferation and apoptosis: dependence on the dose of the inducer. Biochem. Biophys. Res. Commun. 260: 105-110, 1999.

46.      Sinha P, Ghosh AK, Das T, Sa G & Ray PK. Protein A of S. aureus evokes Th1 type response in mice. Immunol. Lett. 67: 157-165, 1999.

47.      Sa G & Das T. Basic FGF stimulates phospholipase A2, phospholipase C-g1 and phos­pholipase D through distinguishable signaling mechanisms. Mol. Cell. Biochem. 198: 19-30, 1999.

48.      Ghosh AK, Sinha P, Das T, Sa G, & Ray PK. S. aureus super­antigen Protein A expand CD4+/CD19+/CD34+ cells in mice- a potential immunorestorer. Biochem. Biophys. Res. Commun. 256: 142-146, 1999.

49.      Subbulakshmi V, Ghosh AK, Das T, & Ray PK. Mechanism of Protein A-induces amelioration of toxicity of anti-AIDS drug. Biochem. Biophys. Res. Commun. 250: 15-21, 1998.

50.      Goenka S, Das T, Sa G, & Ray PK. Protein A induces NO produc­tion: Involvement of tyrosine kinase, phospholipae C and Protein kinase C. Biochem. Biophys. Res. Commun. 250: 425-429, 1998.

51.      Baek KJ, Das T, Gray CD, Desai S, Hwang K-C, Gacchui R, Ludwing M & M-J. A 50 kDa protein modulates guanine nucleotide binding of transglu­taminase II. Biochemistry 35: 2651-2657, 1996.

52.      Nakaoka H, Perez DM, Baek K-J, Das T, Husain A, Misono K, Im M-J & Graham RM. Gh: A GTP-binding protein with transglutaminase activity and receptor signaling function. Science 264: 1593-1596, 1994.

53.      Baek K-J, Das T, Gray CD, Antar S, Murugesan G & Im M-J. Evidence that the Gh protein is a signal mediator from a1-adrenoceptor to a phospholipase C: I. Iden­tification of a1-adrenocep­tor-coupled Gh family and purification of Gh7 from bovine heart. J. Biol. Chem. 268: 27390-27397, 1993.

54.      Das T, Baek K-J, Gray C & Im M-J. Evidence that the Gh protein is a signal mediator from a1-adrenoceptor to a phospholipase C: II. Purification and characteri­zation of a Gh-coupled 69-kDa phospholipase C and reconstitution of a1-adrenoceptor, Gh family and phospholi­pase C. J. Biol. Chem. 268: 27398-27405, 1993.

55.      Sa G, Das T & Mukherjea M. Characterization and binding properties of human fetal lung fatty acid binding proteins. Mol. Cell. Biochem. 129: 67-75, 1993.

56.      Das T, Sa G & Mukherjea M. Characterization of cardiac fatty acid binding protein from human placenta: Comparison with placenta hepatic proteins. Eur. J. Biochem. 211: 725-730, 1993.

57.      Sa G, Das T & Mukherjea M. The evaluation of lung maturity by leci­thin, L/S and PG/PI ratios in human fetus. Med. Sci. Res. 21: 365-366, 1993.

58.      Ghosh PK, Das T, Sa G & Mukherjea M. Gestational variation in the fluidity of human placental brush border membrane: Assessed by lyposomal transfer study.  Med. Sci. Res. 20: 705-706, 1992.

59.      Mukhopadhyay D, Das T, Sa G, Ghosh PK & Mukherjea M. Isolation of fatty acid binding protein from developing human fetal brain. Med. Sci. Res. 20: 641-642, 1992.

60.      Das T, Sa G, Bandhopadhyay AK & Mukherjea M. Relationship between fatty acid binding proteins, acetyl CoA formation and fatty acid synthesis in deve­loping human placenta. J. Biosci. 16: 235-242, 1991.

61.      Sa G, Das T & Mukherjea M. Relationship between fatty acid synthesis, transport and total lipid content during human fetal lung development. Indian J. Biochem. Biophys. 27: 43-47, 1990.

62.      Das T, Sa G, Ghosh PK, Mukhopadhyay D & Mukherjea M. Isolation of fatty acid binding protein from human fetal intestine and heart: Comparison with corresponding hepatic proteins. Med. Sci. Res. 17: 985-986, 1989.

63.      Sa G, Das T & Mukherjea M. Purification and characterization of fatty acid binding protein from human fetal lung. Exp. Lung Res. 15: 619-632, 1989.

64.      Das T, Sa G & Mukherjea M. Human fetal liver fatty acid binding proteins. Role on glucose 6 phosphate dehydrogenase activity. Biochim. Biophys. Acta 1002: 164-172, 1989.

65.      Das T, Sa G & Mukherjea M. Purification and characterization of fatty acid binding protein from developing human placenta. Lipids 23: 528-533, 1988.

66.      Sa G, Das T & Mukherjea M. Ontogenic profile and properties of glucose 6 phosphate dehydrogenase in human fetal tissues. Indian J. Biochem. Biophys. 23: 135-137, 1987.

67.      Das T, Chaudhury I & Mukherjea M. Effect of polyamines on RNA synthesis in human fetal brain. Indian Biologist 18: 40-41, 1986.

68.      Das T & Mukherjea M. Isolation of fatty acid binding protein from developing human placenta and fetal liver. IRCS Med. Sci. 14: 211, 1986.

Book Chapter / Reviews etc.

1.     Das T, Sa G, Saha S, Mukherjee S, Mazumdar M and Mukherjee S. p53, a tumor suppressor at the crossroads of the oncogenic networks in cancer:  Targeting the ‘guardian of the genome’.  Prospective in Cytolology & Genet. 14, (In press) (2010)

2.      Sa G, Das T, Roy P, Banerjee S and Chakraborty J. Oncogenes as molecular target for curcumin-induced cancer cell apoptosis. Prospective in Cytology & Genetics 14, (In press) (2010)

3.     Mohanty S, Adhikary A, Chakrabarty S, Sa G and Das T. Operation ‘p53 Hunt’ to combat cancer: Theaflavins in action. Frontiers in Biosciences (Invited submission) (2010)

4.     Hossain DMS, Bhattacharyya S, Das T, and Sa G. Curcumin: The multi-targeted therapy for cancer regression. Frontiers in Biosciences (Invited submission) (2010)

5.     Das T, Sa G, Saha B and Das K. Multifocal signal modulation therapy of cancer: Ancient weapon, modern targets. Mol. Cell. Biochem. 336, 85–95 (2010)

6.     Sa G, Das T, Banerjee S and Chakrabarty J. Curcumin: From exotic spice to modern anticancer drug. A A J Med Sci. 3, 21-37 (2010)

7.     Parton M, Das T, Sa G, Finke J, Eisen T, Tannenbaum C. Tumour Necrosis Factor - Misnomer and Therapeutic Target. In: Targeted Therapy for Renal Cell Carcinoma (Ed: Dr. R Bukowski). Springer Publishing Company, New York, NY. Chapter 19, 425-488 (2009)

8.     Das T, Sa G, Chattopadhyay S and Saha B. Black tea: The Future Panacea for Cancer. A A J Med Sci. 1, 70-83 (2008) 

9.     Das T, Sa G and Siddiqi M. Potential targets of tea polyphenols in cancer prevention: significance in angiogenesis, metastasis and apoptosis as well as in protection of host defense system. In: Protective effects of tea on human health (Eds. J Weisberger, N K Jain and M Siddiqi) Cabi London, 76-90, 2006 

10.      Bhattacharyya A, Chattopadhyay S and Das T. Tea: A journey across time from beverage to anticancer agent. In: Emerging Pollutants: Impact on Agriculture, Environment and Health (Ed. De A and Gupta S), Allied Publishers, India chapter 15, 157-163, 2006

11.    Lahiry L, Mandal D, Bhattacharyya A, Sa G & Das T. Cancer prevention by cancer regression and rejuvenation of host defense system: Dual role of tea. In: Tea Therapeutics (Eds. B Banerjee & TC Chaudhury) Science Publishers, INC., USA, UK, pp 89-112, 2005

12.      Ray PK, Das T & Sa G. How to activate intrinsic stress resistance mechanisms to obtain thera­peutic benefit.  In: Cell and Molecular Responses to Stress (ed. Storey JM and Storey KB) Elsevier Science, USA, Volume 2, Chapter 14, 2001

13.      Ray PK, Das T, Subbulakshmi V, Ghosh AK, Sa G, Sinha P & Sengupta J. Immunopharmacologic modulation of host response to increase therapeutic index of drugs. In: Immunopharmacology: Strategies for Immunotherapy (Ed. SN Upadhyay), Norosa Publishing House, New Delhi, India, pp 72-84, 1999.

14.      Ray PK & Das T. Molecular adaptation to toxic chemicals and drugs. Adv. Organ Biol. 6: 251-265, 1998.

15.      Ray PK, Goenka S, Das T, Sa G, Sinha P & Srivastava M. Role of nitric oxide in immune func­tion and amelioration of toxicity and carcinogenicity of drugs and chemicals. In: Biological oxidants and anti-oxidants: Molecular mechanisms and health effects. (Ed. L Packer) AOCS Press, USA, Ch.7: 42-53, 1998.

16.      Ray PK, Datta PK, Das T, Srivastava M & V. Subbulakshmi M. Struc­tural analysis of Protein A to localize immunomodulatory motifs. In Immunomodu­lation, (Ed. S.N. Upadhyay) Narosa Press, India, 101-110, 1997.

 Patents

 1. Sa G & Das T. A process for producing therapeutically active pure curcumin from Curcuma longa Linn. The gazette of India, Part III, Section 2, August 30, 2003